癫痫儿童事件相关电位与认知障碍的研究

Study of learning disability and event-related potential in children with epilepsy

目的观察癫痼儿童事件相关电位（ERPP300）和认知障碍，为其临床干预提供试验依据。方法联合应用ERPP300与学习障碍筛查量表（PRS）对85例癫痫儿童和63例健康儿童进行检测，并对2组数据进行统计学比较。结果癫痼儿童PRS量表总分、言语得分、非言语得分及ERPP300潜伏期、波幅与正常儿童相比，差异均有统计学意义（P〈0．01或P〈0．05）。癫痼儿童有痼样放电组较无痼样放电组ERPP300潜伏期明显延长，PRS总分、非言语得分明显降低[（360±48）ms比（334±44）ms，（69±11）分比（76±15）分，（44±7）分比（49±10）分，均P〈0．05]。结论癫痼儿童认知情况受影响，ERPP300潜伏期明显延长，波幅降低；认知受损情况及ERPP300的异常程度与痫样放电关系密切。癫痫的治疗应控制发作与控制痼样放电并重。

Objective To observe the event-related potential（ERP P300） and learning status of epileptic children, in order to provide the experimental basis for clinic intervention. Methods ERP P300 and the pupil rating scale revised screening for learning disabilities （PRS） were done separately in 85 children with epilepsy. Also compare the statistic data between the two groups. Results The latency of ERP P300 in children with epilepsy showed significantly longer than that in the controls （P 〈 0.01 ）. The total score, the verbal score and the nonverbal score of PRS in children with epilepsy showed significantly lower than those in the controls（ P 〈 0.01 ）. The ERP P300 latency, the total score and the nonverbal score of epileptic children with epilcptiform electroencephalographic discharges showed significant difference from those in children without epileptiform discharge （P 〈 0. 05 ）. Conclusions The latency of ERP P300 is significantly delayed and the amplitude of ERP P300 is significantly decreased in children with epilepsy. The condition of damage of their cognitive and learning ruction and the abnormal degree of their ERP P300 is closely related to epitiform discharges.