摘要
目的 探讨小剂量甲氨蝶呤（ Ｍ Ｔ Ｘ） 对 Ｒ Ａ 患者血浆 Ｔ Ｎ Ｆα、 Ｉ Ｌ６ 水平的影响。方法 用放射免疫分析（ Ｒ Ｉ Ａ） 法研究了３０ 例 Ｒ Ａ 患者 Ｍ Ｔ Ｘ（１０ ｍｇ／ Ｗ） 治疗前后血浆 Ｔ Ｎ Ｆα、 Ｉ Ｌ６ 水平的变化。结果 Ｍ Ｔ Ｘ 治疗６ 周后血浆 Ｔ Ｎ Ｆα、 Ｉ Ｌ６ 水平明显降低，以后进一步降低（ Ｐ＜ ００１） 。结论 Ｍ Ｔ Ｘ 能有效地降低 Ｒ Ａ 患者血浆 Ｔ Ｎ Ｆα、 Ｉ Ｌ６ 水平。
Objective To probe the influence of small dose methotrexate (MTX) upon plasma TNFα and IL 6 levels of patients with rheumatoid arthritis (RA).Methods The plasma TNFα and IL 6 level changes were studied by radioimmunologic assay (RIA) in 30 patients with RA before and after treatment of MTX (10 mg/w).Results After 6 weeks when they were treated with MTX,their plasma TNFα and IL 6 level reduced notably,and then continously reduced ( P <0 01).Conclusion Small dose MTX can reduce plsma TNFα and IL 6 levels of the patients with RA,and make their conditions improve.
出处
《中华风湿病学杂志》
CAS
CSCD
1999年第3期177-179,共3页
Chinese Journal of Rheumatology
关键词
甲氨蝶呤
类风湿性关节炎
TNFΑ
IL-6
Methotrexate Arthritis,rheumatoid Tumor necrosis factor Interleukin 6 presence of fibroblast growth factor (FGF) in culturing process.Twelve New Zealand white rabbits were divided into two groups at random.The medial parapatellar was
