急性颅脑损伤后血浆精氨酸加压素和血管紧张素Ⅱ含量变化的临床意义

Clinical significance of changes of arginine vasopressin and angiotensin Ⅱ in acute cerebral injury patients

目的 研究急性颅脑损伤后血浆中精氨酸加压素（ＡＶＰ） 和血管紧张素Ⅱ（ＡＴ－ Ⅱ） 含量的变化及临床意义。方法 用放射免疫法（ＲＩＡ） 检测７５ 例急性颅脑损伤患者，３０ 例非颅脑损伤患者和３０ 例健康者的血浆中ＡＶＰ和ＡＴ－ Ⅱ含量，进行分析和观察其临床意义。结果 ７５ 例急性颅脑损伤后血浆中ＡＶＰ和ＡＴ－ Ⅱ含量明显高于非颅脑损伤组（ Ｐ＜ ００１） ，非颅脑损伤组高于健康者组（ Ｐ＜ ００１） 。急性颅脑损伤组中ＡＶＰ和ＡＴ－ Ⅱ含量与ＧＣＳ评分负性相关。结论 ＡＶＰ和ＡＴ－ Ⅱ参与了颅脑损伤的病理生理过程，病情越严重，血浆中ＡＶＰ和ＡＴ－ Ⅱ含量越高。提示ＡＶＰ和ＡＴ－ Ⅱ也可作为观察急性颅脑损伤严重程度的指标之一。

Objective A study of changes and its clinical significance of arginine vasopressin (AVP) and angiotensin Ⅱ(AT-Ⅱ) in acute cerebral injury patients.Methods 75 patients with acute cerebral injuries,30 trauma patients without cerebral injuries and 30 healthy volunteers.Results The plasma concentration of AVP and AT-Ⅱ in acute cerebral injury patients is higher than the concentration of trauma patients without cerebral injuries( P <0 01).Also,the plasma level of AVP and AT-Ⅱ in the trauma patients without head injuries is higher than the level of healthy volunteers( P <0 01).The level of AVP and AT-Ⅱ in acute cerebral injury patients negatively relates to the GCS scores.Conclusions The study suggests that AVP and AT-Ⅱ may play an important role in the pathiophysiologic process in the cerebral injury patients.The more severe the cerebral injury,the higher the level of AVP and AT-Ⅱ.It also indicates that the level of AVP and AT-Ⅱ may be one of the severity indexes of cerebral injury patients. [