急性脑血管病肿瘤坏死因子水平及临床意义

Serum levels oftumor necrosisfactorin patients with acute cerebrovascular disease andits clinicalsignificance

目的 探讨肿瘤坏死因子（ＴＮＦ） 与急性脑血管病的关系。方法 测定５０ 例急性脑血管病患者血清ＴＮＦ 浓度，同时以３０ 名健康献血员及门诊体检者为对照组，结果以ｔ 检验作统计学分析。结果 各组脑血管病患者血清ＴＮＦ水平均较对照组（０ ．７４ ±０ ．１５ ｎｇ／ｍｌ） 显著升高（ Ｐ＜ ０００１） ，且与病情程度明显相关。结论 揭示ＴＮＦ参与急性脑血管病的病理生理过程，ＴＮＦ动态观察，可能是判断预后的重要因素。

Objective To reseach the relationship between acute cerebrovascular diseases (ACVD) and the serum levels of tumor necrosis factor (TNF) .Methods The levels oftumor necrosis factor were measured in 50 patients with acute cerebrovascular disease .Thirty health persons served as control group were studied simultaneously .The test was used for statistical analysis .Results The serum levels oftumor necrosis factor were significantly ( P< 0 .001) higher in acute cerebrovascular disease than thosein controls (0 74 ±0 15ng/ml) .Levels oftumor necrosisfactor might have an evidentcorrelation with the sever ity of ACVD.Conclusion The tumor necrosisfactor might play an importantrole in the pathological process of ACVD.It was helpfulto decide the prognosis of ACVDthatserum levels oftumor necrosisfactor determined continuously . [