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5-芳基-3-羟基异噁唑的合成 被引量：2

Synthesis of 5-aryl-substituted-3-hydroxy-isoxazoles
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摘要 以不同取代的苯甲醛为起始原料,经wittig反应,溴加成,关环得到5-芳基-3-异噁唑醇.报道了对5个5-芳基-3-羟基噁唑化合物的新合成路线,这些目标化合物结构均经1H NMR和MS表征.并对化合物的wittig反应机理和关环反应机理进行了讨论. Five 5–aryl-substituted-3-hydroxy-isoxazoles were synthesized from aromatic aldehydes by means of wittig reaction,bromide reaction,and cyclization.All of the target compounds have been confirmed by 1H NMR,MS spectrums and elementary analysis.In addition,the possible mechanism of wittig reaction and the cyclization route was discussed.
作者 李阳 黄翔 陈达 龚占强 巨修练
机构地区 武汉工程大学化工与制药学院绿色化工过程省部共建教育部重点实验室
出处 《武汉工程大学学报》 CAS 2011年第5期18-21,共4页 Journal of Wuhan Institute of Technology
关键词 异噁唑 合成 杂环化合物 isoxazole synthesis heterocyclic compounds
分类号 O626.13 [理学—有机化学]
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参考文献14

  • 1洪艳平,宋宝安,刘楠,颜贤仔,龙小艺.异噁唑类农药生物活性研究进展[J].安徽农业科学,2006,34(2):281-283. 被引量：7
  • 2Mathews A,Sasikala K A,George S C,et al.The Reaction of 2-Aroyl-3,3-bis (alkylsulfanyl)acrylaldehydes And Hydroxylamine Hydrochloride:Facile Synthesis of Differently Substituted Isoxazoles[J].Heterocyclic Chem,2008,45(6):1583-1588.
  • 3Zlotin S G,Kislitsin P G,Luk'yanov O A.Palladium-catalyzed reaction of bromine-and iodinecontaining isothiazoles with olefins[J].Russ Chem Bull,1998,47(3):517-519.
  • 4Lee Y S,Hyean K B.Heterocylic Nucleoside Analogues:Design and Synthesis of Antiviral,Modified Nucleosides Containing Isoxazole Heterocycles[J].Bioorg Med Chem Lett,2002,12:1395-1397.
  • 5Jiang H,Luo X,Bai D.Progress in clinical,pharamacological,chemical and structural biological studies of huperzine A:a drug of traditional chinese medicine origin for the treatment of Alzheimer's disease[J].Current Med Chem,2003,10(21):2231-2252.
  • 6Hiroyuki K,Tsuneo I,Nobuo M,et al.Synthesis and Fungicidal Activities of 3-(α-Alkoxyiminobenzyl)isoxazole Derivatives[J].Pestic Sci,1999,24:130.
  • 7Henry W T,Hatzios K K.Comparative effects of three isoxazole-herbicidal derivatives on the metabolism of enzymatically isolated-urea herbicidal derivatives on the metabolism of enzymatically isolated soybean leaf cels[J].Weed Research,1987,27(1):23 -30.
  • 8齐传民,王蕴峰,张关心,冯淑娟.新型异恶唑类化合物的合成及其生物活性的研究[J].北京师范大学学报（自然科学版）,2001,37(6):787-789. 被引量：11
  • 9Sφrensen U S,Falch E,Krogsgaard-Larsen P.A Novel Route to 5-Substituted 3-Isoxazolols.Cyclization of N,O-DiBoc a-Keto Hydroxamic Acids Synthesized via Acyl Meldrum's Acids[J].Org Chem,2000,65(4):1003-1007.
  • 10刘长令,袁英慧.异噁唑类除草剂的创制经纬[J].农药,2002,41(7):42-42. 被引量：4

二级参考文献18

  • 1黄震年,李正名.1－（取代异噁唑基）－1，2，4．三唑和1－（取代嘧啶基）－1，2，4－三唑的合成及生物活性[J].高等学校化学学报,1995,16(11):1740-1743. 被引量：3
  • 2阮朗.异(口恶)唑二羧酸衍生物的合成及除草活性研究[J].农药译丛,1996,18(1):33-38. 被引量：5
  • 3Wang Yunfeng，Chin Chem Lett，1998年，9卷，9期，803页
  • 4Willms L, Bauer K, Bieringer H, et al. Substituted isoxazolines,process for their preparation, composition containing them, and their use ofsafeners[P], US5516750, 1996-05-14.
  • 5Zhou Y, Miao W R, Wang Zh Q. A series of herbicidal compounds of substituted phenylpyrazole [P]. CN1402979, 2003-03-19.
  • 6Maywald V, Muenster P, Koenig H, et al. Isoxazole and isothiazole-5-carboxamides [P]. US5399544, 1995 -03-21.
  • 7EI-Gaby M A, Micky J, Taha N, et al. Antimicrobial activity of some novel thiourea, hydrazine, fused pyrimidine and 2-(4-substituted)anilinobenzoazole derivatives containing sulfonamide moieties [J]. J Chin Chem Soc, 2002, 49: 407-414.
  • 8Lee S. Isoxazole derivatives and their use as herbicides[P]. US 6297198.2001-10-02.
  • 9David M, Bipin P. Isoxazole derivatives and their use as pesticides[P].EP0555931, 1993-08-18.
  • 10Tsuboi S, Moriya K, Hattori Y, et al. Insecticidal guanidine derivatives [P]. US 5472971, 1995-12-05.

共引文献17

同被引文献24

  • 1SUCHAIL S,GUEZ D,BELZUNCES L P.Discr-epancy between acute and chronic toxicity induced byimidacloprid and its metabolites in Apis mellifera[J].Environmental Toxicology and Chemistry,2001,20(11): 2482-2486.
  • 2OLDROYD B P.What's killing American honey-bees? [J].PLOS Biol,2007 (5): 1195-1199.
  • 3FAUCON J P,AURI,RES C,DRAJNUDEL P,et al.Experimental study on the toxicity of imid-acloprid given in syrup to honey bee (Apis mellifera)colonies [J].Pest Management Science,2005,61(2): 111-125.
  • 4NAUEN R,EBBINGHAUS-KINTSCHER U,SC-HMUCK R.Toxicity and nicotinic acetylcholinereceptor interaction of imidacloprid and its metabo-lites in Apis mellifera (Hymenoptera: Apidae) [J].Pest Managment Science,2001,57(7):577-586.
  • 5VANENGELSDORP D,EVANS J D,SAEGERM-AN C,et al.Colony collapse disorder: a descriptivestudy[J].Plos One,2009,4(8) : 1-17.
  • 6UNWIN N.Refined structure of the nicotinic acetyl-choline receptor at 4人 resolution [ J].Journal ofMolecular Biology,2005,346(4) : 967-989.
  • 7UNWIN N,MIYAZAWA A,LI J,et al.Activationof the nicotinic acetylcholine receptor involves aSwitch in conformation of the alpha subunits [J].Journal of Molecular Biology,2002,319 (5):1165-1176.
  • 8TOMIZAWA M,LEE D L,CASIDA J E.Neoni-cotinoid insecticides: molecular features conferringselectivity for insect versus mammalian nicotinicreceptors [ J].Journal of Agricultural and FoodChemistry,2000,48(12) : 6016-6024.
  • 9SATTELLE D B.Invertebrate nicotinic acetylcholinereceptors-targets for chemicals and drugs importantin agriculture,veterinary medicine and humanhealth[J].Journal of Pesticide Science,2009,34(4): 233-240.
  • 10CORRINGER P J,LE NOVERE N,CHANGE-UX J P.Nicotinic receptors at the amino acid level[J].Annual Review of Pharmacology and Toxic-ology,2000, 40:431-458.

引证文献2

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武汉工程大学学报
2011年 第5期

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