摘要
目的研究溶栓治疗对急性心肌梗塞(AMI)早期心脏自主神经功能的影响。方法采用时域法研究AMI溶栓治疗再通组、未通组、及AMI未作溶栓治疗的对照组患者心梗后24小时内的心率变异性(HRV)。结果溶栓再通组24小时全部窦性RR间期(NN)均值的标准差(SDNN)、24小时所有5分钟窦性RR间期均值的标准差(SDANN)、24小时相邻窦性RR间期标准差的平方根(rMSSD)、逐次的窦性RR间期改变>50ms的百分比(PNN_50)较溶栓未再通组及对照组均显著提高(P<0. 01);溶栓未再通组 SDNN、 SDANN、rMSSD、 PNN50与对照组比较无明显差异(P>0.05)。结论溶栓再通灌注能显著提高AMI患者早期HRV、改善心脏自主神经的功能。
Objective: To investigate the effect of thrombolytic therapy on autonomous function within 24 hours of the onset of acute myocardial infarction Methods: Time domain analysis of heart rate variablity studied in patients showed evidence of reperfusion and that who failed to reper fuse treated with rt-PA intravenous thrombolytic therapy and those as compared group who were not thrombolyzed. Results: Patients with evidence of reperfusion had significantly higher SD of all normal RR intervals in the entire 24-hour recording (SDNN), SD of the mean of all 5 minute segments of normal RR intervals in a 24-hour recording (SDANN),the square root of the mean of the sum of the squares of differences between adjacent RR intervals differing by >50ms (PNN50) comparing with patients failed to reper fuse and those who were not thrombolyzed (P<0. 01), the HRV measurement in patients failed to repterfuse were similar to those obtained in patients with AMI who were not thrombolyzed (P>0.05). Conclusion: Successful reperfusion after rt-PA intravenous thrombolytic therapy significantly increcsed HRV and had a great beneficial effect on autonomous function following acute myocardial infarction.
出处
《福建医药杂志》
CAS
1999年第4期92-93,共2页
Fujian Medical Journal
关键词
心肌梗塞
心脏自主神经
溶栓疗法
Acute myocardial infarction Autonomous nerve system Heart rate variability Thrombolytic therapy