洛沙坦与苯那普利治疗原发性高血压左室肥厚的对比研究

Comparative Study on the Different Effect between Losartan and Benazepril in the Hypertensive Patients with Left Ventricular Hypertrophy

评价洛沙坦治疗高血压左室肥厚的疗效并与苯那普利作比较。原发性高血压左室肥厚患者５０例，随机分为洛沙坦治疗组（２５～５０ｍｇ／ｄ）、苯那普利治疗组（５～２０ｍｇ／ｄ），疗程 ４个月，结果洛沙坦或苯那普利治疗后血压比治疗前显著降低，两组对左室肥厚的逆转率分别为８０％与７２％，逆转作用无差别，不良反应发生率洛沙坦比苯那普利明显减少。本文资料显示，洛沙坦是降低血压、逆转左室肥厚疗效较好的药物。

To compare the effect of losartan and benazepril on the left ventricular hypertropy (LVH) in hypertensive patients. 50 patients were treated with losartan (n=25, 25-50mg/d) and benazeprit (n=25, 10-20mg/d) for 4 months. Our results showed that treatment with both drugs not only decreased blood pressure,but also regressed LVH significantly, the effective rate were 80% and 72% respectively(p>0.05). A lower incidence of adverse effects was observed in losartan group. Our data revealed that losartan is an effective antihypertensive agent in essential hypertension with LVH.