过敏性鼻炎患者血清SIgE和ECP水平的关系探讨

Relationship between serum SIgE and serum ECP in allergic rhinitis patients

目的：分析过敏性鼻炎（ Ａ Ｒ） 患者血清特异性 Ｉｇ Ｅ（ Ｓ Ｉｇ Ｅ） 和嗜酸粒细胞阳离子蛋白（ Ｅ Ｃ Ｐ） 的关系。方法：采用荧光酶联法对３８ 例 Ａ Ｒ 患者进行吸入性过敏原过筛试验、 Ｓ Ｉｇ Ｅ 和血清 Ｅ Ｃ Ｐ 含量测定。结果：吸入性过敏原过筛试验阳性率为９４ ．７ ％ 。１０例对单一变应原有反应，２６ 例检出２ ～６ 种变应原（ 户尘螨、屋尘、普通豚草、蒿草、藜草和动物皮毛屑） 的 Ｓ Ｉｇ Ｅ，测定值为０ ．３５～６３ ．６ Ｋ Ｕ／ Ｌ，血清 Ｅ Ｃ Ｐ水平为２４ ．８７ ±１０ ．５５ μｇ／ Ｌ，健康对照组为９ ．９３ ±５ ．６２ μｇ／ Ｌ，两组有显著性差异（ Ｐ＜ ０ ．０１） 。临床观察， Ｓ Ｉｇ Ｅ 含量与患者症状及体征无明显相关性，但患者的咳喘程度与血清 Ｅ Ｃ Ｐ 的浓度有关，血清中 Ｓ Ｉｇ Ｅ 含量与 Ｅ Ｃ Ｐ浓度间相关性分析没有统计学意义（ｒ＝ ０ ．１０４７ ， Ｐ＞ ０ ．０５） 。结论：检查血清 Ｉｇ Ｅ 对过敏性鼻炎特异性病因诊断是非常重要的，也对该病病程发展和治疗监测有一定的参考意义。

Purpose:To explore the relationship between serum specific IgE(SIgE) and serum eosinophile cationic protein(ECP) levels in patients with allergic rhinitis(AR). Methods:Serum SIgE,serum ECP and phadiatop were measured by pharmacia CAP system FEIA.Results:The positivity of phadiatop was 94.7%.One kind of SIgE was detected in 10 patients ,2-6 kinds of serum SIgE were detected in 26 patients.The pollens were house dust mute,house dust,common regweed ,mugwort,lamb's quarters and animal danders.The mean ECP level in 38 patients was significantly higher than that in controls 24.87±10.55 μg/L per 9.93±5.62 μg/L( P <0.01).According to clinical observation,serum SIgE level didn't correlated with the symptoms and signs of patients,but the severity of asthma dose correlated with the serum ECP level,and the serum SIgE level didn't correlated with serum ECP level( r =0.1047, P >0.05). Conclusion:The use of pharmacia CAP phadiatop is important for the diagnosis of AR.ECP is not a specific marker for the diagnosis of AR,but however,it is helpful to evaluate the development and to monitor the therapy in AR patients.