利伐沙班联合非洛地平预防断指再植术后小动脉危象的疗效研究

The effects of rivaroxaban combining felodipine in prevention of arteriolar crisis after reimplantation of amputated fingers

目的探讨利伐沙班联合非洛地平预防断指再植术后动脉危象的疗效,并对药物的副作用进行观察。方法 2009年8月～2010年8月,研究组65例断指再植患者术后应用利伐沙班联合非洛地平预防术后动脉危象,对照组78例断指再植患者术后应用罂粟碱、肝素钠预防术后动脉危象,观察记录断指再植动脉危象发生情况、成活情况、药物副作用,进行统计学分析。结果研究组较对照组再植指体血管危象发生率低,断指再植成活率高,药物副作用少。结论利伐沙班联合非洛地平在断指再植术后应用,能够降低断指再植术后小动脉危象的发生率,同时药物副作用少,患者对药物的依从性及耐受性好。

Objective To determine the effects and side effects of combination of rivaroxaban and felodipine in preventing arteriolar erisis after amputated fingers reimplantation. Methods From August 2009 to August 2010, 65 patients who had reimplantation of amputated fingers, received rivaroxaban and felodipine to prevent vascular crisis, while the other 78 patients received papaverine and heparin sodium as control group. The side effects, the rate of vascular crisis, and the survival rates were all recorded and analysed by statistical method, Results The rate of vascular crisis was lower, while the survival rate was much higher in the experimental group than in the control group. The side effects were quite fewer in the experimental group than in the control group. Conclusions Rivaroxaban combining felodipine can decrease the rate of arteriolar crisis in amputated fingers reimplantation with fewer side effects. Good compliance and tolerance of patients can also be achieved.