丁公藤注射液的药动学相关性研究

Correlation Studies on Pharmacokinetics of Dinggongteng Injection (Erycibe Obtusifolia Benth.) between Two Methods

用药物累积法与血药浓度法对丁公藤注射液进行药动学相关性研究，结果表明：在０．５～８ｈ之间，血药浓度时间曲线与体存量时间曲线存在一定的线性相关关系，提示血药浓度法与药物累积法的测定结果在一定时间范围内具有相关性；由于两法选择指标的不同，加上酶饱和动力学因素的影响，两法一房室模型的动力学参数存在差异。

The correlation in pharmacokinetics of Dinggongteng Injection was studied by drug cumulative method and blood drug concentration method. As a result, a linear correlation exists between the blood drug concentration time curve and remnant quantitative time curve from 0.5- 0.8 hours, which indicated that a correlation exists in the data got by two methods at certain time. As differences in indexes and effects of enzymatic saturation kinetics, the kinetic parameters of one compartment open model of two methods are different.