EV71感染的手足口病患儿体液免疫临床分析

Clinical analysis on humoral immunity in children with hand-foot-mouth disease by EV71 infection

目的探讨并分析EV71感染手足病患儿体液免疫状况。方法分别测定30例EV71阳性和30例EV71阴性的手足口病患儿与同期20例健康儿童的血清IgG、IgA、IgM及补体C3、C4水平,采用SPSS18.0软件用t检验统计分析EV71阳性组的IgG、IgA、IgM及补体C3、C4水平与EV71阴性组和对照组各项指标水平的差异。结果 EV71阳性组和阴性组手足口病患儿各指标水平无显著差异;与对照组相比,EV71阳性组患儿血清IgG、IgA、C3、C4水平降低(P<0.05);IgM明显升高(P<0.001)。结论 EV71感染的手足口病患儿存在体液免疫功能紊乱,但EV71感染对体液免疫功能影响无显著特异性。

Objective To discuss the function of humoralimmunity in children with hand-foot-mouth disease（HFMD）caused by EV71 infection.Methods Levels of IgG,IgA,IgM and C3,C4 were detected,respectively,in 30 children with HFMD of EV71 positive,30 children with EV71 negative and 20 normal cases of healthy children.T test was used to analyze the differences of IgG,IgA,IgM and C3,C4 with levels among the EV71 positive group,EV71 negative group and control group by SPSS 18.0.Results There were no significant differences on serum levels of IgM,IgG,IgA,C3 and C4 between HFMD children with EV71 positive and EV71 negative.Serum levels of IgG,IgA,C3 and C4 were significantly reduced compared with those of normal controls（P〈0.05）,but serum level of IgM was significantly increased（P〈 0.001）.Conclusions The humoralimmunity function of children disordered after EV71 infection.But the influence to humoral immune function has no significant specificity.