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急性白血病FLT3/ITD、C-Kit基因突变预后相关性的研究 被引量：3

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摘要 目的探讨FLT3内部串联重复(internal tandem duplication,ITD)与C-Kit基因突变与急性白血病突变预后相关性。方法利用PCR扩增技术结合DNA测序技术分析33例急性髓系白血病(AML),13例急性淋巴细胞白血病(ALL),急性混合细胞白血病6例患者骨髓单个核细胞中FLT3/ITD基因与C-Kit基因突变率,分析FLT3/ITD基因与C-Kit基因突变阳性患者的表达水平及疗效。结果急性髓系白血病(AML)患者的FLT3/ITD基因及C-Kit基因平均表达水平高于急性淋巴细胞白血病患者(P<0.05)。33例初治急性白血病FLT3/ITD阳性及C-Kit阳性的患者治疗后缓解率低于阴性患者。结论 FLT3/ITD及C-Kit基因是急性白血病中常见的基因突变类型,均属于III型受体酪氨酸激酶家族成员,与白血病的发生及预后有相关性。
作者 刘宁 赖永榕
机构地区 广西医科大学 广西医科大学一附院
出处 《中外医学研究》 2011年第15期28-30,共3页 CHINESE AND FOREIGN MEDICAL RESEARCH
关键词 急性髓系白血病 FLT3/ITD基因 C-KIT基因
分类号 R733.71 [医药卫生—肿瘤]
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参考文献18

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二级参考文献5

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共引文献8

同被引文献24

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引证文献3

二级引证文献8

中外医学研究
2011年 第15期

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