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ADAM33基因位点单核苷酸多态性与山东地区支气管哮喘患者的相关性 被引量:8

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摘要 支气管哮喘(简称哮喘)是一种受环境因素和遗传因素双重影响的疾病,与多基因遗传有关。解整合素一金属蛋白酶33(ADAM33)基因是近年来新发现的ADAM家族成员,与气道高反应性和哮喘密切相关[1]。本研究中应用现代分子生物学方法,对ADAM33基因F+1、S2、T2和V4位点多态性进行检测,旨在了解ADAM33基因单核苷酸多态性(SNP)与哮喘的相关性,从而在分子水平探索遗传因素在哮喘发病中的作用。
出处 《中华结核和呼吸杂志》 CAS CSCD 北大核心 2011年第5期386-387,共2页 Chinese Journal of Tuberculosis and Respiratory Diseases
基金 基金项目:山东省自然科学基金(Y2006C74)
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参考文献7

  • 1Van Eerdewegh P, Little RD, Dupuis J, et al. Association of the ADAM33 gene with asthma and bronchial hyperresponsiveness. Nature, 2002, 418:426-430.
  • 2中华医学会呼吸病学分会哮喘学组.支气管哮喘防治指南(支气管哮喘的定义、诊断、治疗及教育和管理方案)[J].中华结核和呼吸杂志,2003,26(3):132-138. 被引量:3562
  • 3Yoshinaka T, Nishii K, Yamada K, et al. Identification and characterization of novel mouse and human ADAM33s with potential metalloprotease activity. Gene, 2002, 282:227-236.
  • 4Hirota T, Hasegawa K, Obara K, et al. Association between ADAM33 polymorphisms and adult asthma in the Japanese population. Clin Exp Allergy, 2006, 36:884-891.
  • 5邱玉明,罗雅玲,赖文岩,邱士军,吴月仙.ADAM33基因Met764Thr位点多态性与支气管哮喘发病及患者肺功能的相关性[J].中华结核和呼吸杂志,2007,30(7):518-521. 被引量:22
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二级参考文献9

  • 1Van Eerdewegh P, Little RD, Dupuis J, et al. Association of the ADAM33 gene with asthma and bronchial hyperresponsiveness. Nature,2002,418:426-430.
  • 2Werner M, Herbon N, Gohlke H, et al. Asthma is associated with single-nucleotide polymorphisms in ADAM33. Clin Exp Allergy, 2004,34:26-31.
  • 3Lee JH, Park HS, Park SW, et al. ADAM33 polymorphism: association with bronchial hyper-responsiveness in korean asthmatics. Clin Exp Allergy,2004,34:860-865.
  • 4Wolfsberg TG, Primakoff P, Myles DG, et al. ADAM, a novel family of membrane proteins containing a disintegrin and metalloprotease domain: muhipotential functions in cell-cell and cell-matrix interactions. J Cell Biol, 1995,131:275-278.
  • 5Yoshinaka T, Nishii K, Yamada K, et al. Identification and characterization of novel mouse and human ADAM33s with potential metalloprotease activity. Gene,2002,282:227-236.
  • 6Hirota T, Hasegawa K, Obara K, et al. Association between ADAM33 polymorphisms and adult asthma in the Japanese population. Clin Exp Allergy ,2006,36:884-891.
  • 7Jongepier H, Boezen HM, Dijkstra A, et al. Polymorphisms of the ADAM33 gene are associated with accelerated lung function decline in asthma. Clin Exp Allergy,2004,34:757-760.
  • 8Simpson A, Maniatis N, Jury F, et al. Polymorphisms in a disintegrin and metalloprotease 33 ( ADAM33 ) predict impaired early-life lung function. Am J Respir Crit Care Med ,2005,172:55- 60.
  • 9中华医学会呼吸病学分会哮喘学组.支气管哮喘防治指南(支气管哮喘的定义、诊断、治疗及教育和管理方案)[J].中华结核和呼吸杂志,2003,26(3):132-138. 被引量:3562

共引文献3577

同被引文献118

  • 1邱玉明,罗雅玲,赖文岩,邱士军.中国华南地区汉族人群支气管哮喘患者ADAM33基因T_1位点多态性研究[J].南方医科大学学报,2007,27(4):485-487. 被引量:5
  • 2邱玉明,罗雅玲,赖文岩,邱士军,吴月仙.ADAM33基因Met764Thr位点多态性与支气管哮喘发病及患者肺功能的相关性[J].中华结核和呼吸杂志,2007,30(7):518-521. 被引量:22
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  • 7Gooz P, Gooz M, Baldys A, et al. ADAM-17 regulates endotheli- al cell morphology, proliferation, and in vitro angiogenesis [J ]. Biochem Biophys Res Commun, 2009,380( 1 ) : 33-38.
  • 8Van Eerdewegh P, Little RD, Dupuis J, et al.Association of the ADAM33 gene with asthma and bronchial hyperresponsive- ness [J].Nature,2002,418(6896):426-430.
  • 9Holgate ST, Yang Y, Haitchi HM, et al.The genetics of asthma: ADAM33 as an example of a susceptibility gene [J]. Proc Am Thorac Soc, 2006,3(5 ) : 440-443.
  • 10Puxeddu I, Pang YY, Harvey A, et al.The soluble form of a disin- tegrin and metalloprotease 33 promotes angiogenesis: implica- tions for airway remodeling in asthma [J].J Allergy Clin Immu- nol, 2008,121 (6) : 1400-1406.

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