摘要
目的探讨2型糖尿病(T2DM)患者血清8-羟基脱氧鸟苷酸(8-OHdG)与胰岛素抵抗(IR)和颈动脉内膜中层厚度(IMT)的相关性。方法 50例初诊T2DM患者根据IMT分成A组(IMT<1.0 mm,32例)和B组(IMT≥1.0 mm或存在硬化斑块,18例);正常对照组(C组,25例)。检测三组血清8-OHdG水平、体重指数(BMI)、空腹血糖(FBG)、血脂、胰岛素(Ins)、糖化血红蛋白(HbA1c),计算胰岛素抵抗指数(Homa-IR)。结果 A组和B组的血清8-OHdG水平均显著高于C组,且B组较A组显著升高(P<0.05);血清8-OHdG水平与Homa-IR和IMT呈正相关(P<0.05)。8-OHdG、Homa-IR、HbA1c、总胆固醇(TC)为IMT的风险预测因子。结论血清8-OHdG水平增高与IR和颈动脉IMT的增厚相关,提示氧化应激参与了IR的形成及T2DM并发症的发生。
Objective To investigate the correlation between serum 8-hydroxy-guanine（8-OHdG） and insulin resistance （IR） and intima-media thickness（IMT） of the carotid artery in patients with type 2 diabetes mellitus（T2DM）.Methods The concentrations of fasting blood glucose（FBG）,blood lipid,insulin（Ins）,glycolated hemoglobin（HbA1c） and serum 8-OHdG were measured and body mas index and insulin resistance index（Homa-IR） were calculated in 25 healthy subjects（group C） and 50 T2DM patients,who were divided into groups of A（32 cases,IMT1.0 mm） and B（18 cases,IMT≥1.0 mm or having atheromatous plaque）.Results Serum 8-OHdG was significantly higher in groups of A and B than that in group C,which was significantly higher in group B than that in group C（P0.05）.Serum 8-OHdG level was positively correlated with Homa-IR and IMT.Stepwise multiple regression analysis showed that 8-OHdG level,Homa-IR,HbA1c and TC were the risk factors for IMT.Conclusion The increased level of serum 8-OHdG is correlated with insulin resistance and increased IMT of the carotid artery,indicating that oxidative stress participates in the formation of insulin resistance and occurrence of diabetic complications.
出处
《江苏医药》
CAS
CSCD
北大核心
2011年第10期1175-1177,共3页
Jiangsu Medical Journal
