核酸适配体及其在病原微生物学中的应用

Aptamers:characteristics and applications in pathogenic microorganism

核酸适配体指利用指数富集配体系统进化技术筛选出的寡聚核苷酸片段,它可以特异性地识别靶标并与之结合,已经广泛应用于基础研究、临床诊断、纳米技术等。以下综述了适配体在微生物学方面的应用。

Aptamers are a group of artificial oligonucleotides identified by exponential enrichment system evolution technology（Selective expansion of ligands by exponential enrichment,SELEX）.Aptamers have been widely used in basic research,clinical diagnostics,and nano-technology.In this article we will introduce the technology of aptamer and summarize its applications in medical microbiology.