体脂分布与血脂代谢的相关性研究

The study of relationship between body fat composition and serum lipid

目的:利用双能X线吸收法(dual-energy X-ray absorptiometry,DEXA)测量体脂分布,分析冠心病与对照组男、女两性不同体脂分布及脂代谢特点。方法:将85位受试者分为冠心病组及对照组,逐一测量身高、体质量、腰围(WC)、臀围(WH)、计算体质量指数(BMI)及腰臀比(WHR);利用DEXA法记录不同部位脂肪含量,计算全身脂肪比例(Total Fat%),腰臀部脂肪比(A/G);检测总胆固醇(TC)、三酰甘油(TG)、高密度脂蛋白胆固醇(HDL-C)及低密度脂蛋白胆固醇(LDL-C)各项血脂指标。比较2组间体脂、血脂测量指标差异,并分别比较2组间及冠心病组内男性和女性的体脂分布差异,行体脂与血脂的相关性分析。结果:冠心病组的WC、A/G均高于对照组,差异有统计学意义(P<0.05)。冠心病组男性的BMI、WC、WHR及A/G高于健康人组男性,差异有统计学意义(P<0.05),2组女性间比较各体脂指标之间差异无统计学意义。冠心病组内男性WC、WHR高于女性,差异有统计学意义(P<0.05)。男性HDL-C与A/G、WHR呈显著负相关(P<0.05)。结论:男、女两性体脂分布特点不同,男性更易患腹型肥胖,引起高TG、低HDL为特点的脂代谢紊乱,与冠心病密切相关。

Objective：The aim of this study is to investigate the body fat composition and distribution in subjects with Dual-energy X-ray Absorptiometry（DEXA）and the difference of the body fat composition and dis-tribution between the male and the female,the disease group and the control group.Methods：85 persons were divided into the disease group and the control group.All subjects were observed to survey the height,body weight,waist circumference（WC）,hip circumference（HP）,then calculated the body mass index（BMI） and the waist-to-hip ratio（WHR）.All subjects were evaluated with a DEXA total body scan performed using a Lu-nar Prodigy system（GE Healthcare）.All subjects were collected venous blood to assay fasting total cholesterol（TC）,triglyceride（TG）,high density lipoprotein cholesterol（HDL-C）,low density lipoprotein cholesterol（LDL-C）.The data of the body fat composition and distribution were analyzed between the male and the fe-male,the disease group and the control group.The relation of the body fat composition and distribution with Se-rum lipid are also analyzed.Results：The disease group＇s WC,A/G is significantly higher than the control.The male in the CHD group＇s BMI,WC,WHR,A/G are significantly higher than the control group.The female＇ body fat composition between the disease group and the control group are not significantly deference.In the disease group,the male＇s WC,WHR is significantly higher than the female＇s.The level of male＇s HDL-C is significantly correlated with A/G,WHR.Conclusion：The fat content of the male was higher than the one of the female,of which Intra-abdominal fat was obviously higher than the female,therefore the male risk of the diseases related to the obese trunk was higher than the female one.The accumulation of abdominal adipose tissue is closely corre-lated to higher TG and lower HDL-C.