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他汀类药物早期治疗脑梗死的疗效 被引量:2

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摘要 目的探讨早期使用他汀类药物治疗脑梗死的临床疗效。方法将90例患者随机分成治疗组和对照组各45例,在常规治疗基础上,治疗组予辛伐他汀20 mg/d或阿托伐他汀10 mg/d,对照组未用他汀类药物。治疗前后作临床疗效比较,神经功能缺损评分,测定C反应蛋白水平。结果治疗组显效率、有效率均高于对照组:两组治疗前后神经功能缺损比较差异有显著性;C反应蛋白水平比较差异有显著性。结论早期使用他汀类药物可改善神经功能,提高临床疗效,应长期使用。
作者 卢云甫
出处 《齐齐哈尔医学院学报》 2011年第5期733-734,共2页 Journal of Qiqihar Medical University
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  • 1各类脑血管疾病诊断要点[J].中华神经科杂志,1996,29(6):379-380. 被引量:33004
  • 2脑卒中患者临床神经功能缺损程度评分标准(1995)[J].中华神经科杂志,1996,29(6):381-383. 被引量:15736
  • 3Deplanque D,Masse I,Lefebvre C,et al.Prior TIA,lipid-lowering drug use,and physical activity decrease ischemic stroke severity[J].Neurology,2005,67:1404-1410.
  • 4Ovbiagele B,Saver JL,Starknan S,et a1.Statin enhancement of collateralization in acute stroke[J].Neurology,2003,68:2129-2131.
  • 5Wojnicz R,Wilczek K,Nowalany-Kozielska E,et aI.Usefulness of atolwastatln in patients with heart failure due to inflammatory dilated ardiomyopathy andelevated cholesterol levels[J].Am J Cardiol,2006,15,97(6):899-904.
  • 6Ludwig A,Friedel B,Metzkow S,et al.Effect of statlns on the proteasomal ctivity in mammalian endothelial and vascular,smooth muscle cells[J].Biochem Pharmacol,2005,70(4):520-526.
  • 7Dirnagl U,Iadecola C,Moskowitz MA.Pathobiology of ischaemic stroke:an integrated view[J].Trends Neurosci,2004,22:391-397.
  • 8Endres M.Statins:Potential new indications in inflammatory conditions[J].Atheroscler Suppl,2006,7(1):31-35.

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  • 1Ariyarajah V,Dawe DE,Khadem A. Is there a role for statins in atrialfibrillation[J].Pacing and Clinical Electrophysiology,2009.1063-1072.
  • 2Gürgün C,Ildizli M,Yavuzgil O. The effects of short term staintreatment on left ventricular function and inflammatory markers in Patients with chronic heart failure[J].International Journal of Cardiology,2008.102-107.
  • 3Fuster V,Rydén LE,Cannom DS. 2011 ACCF/AHA/HRS focused updates incorporated into the ACC/AHA/ESC 2006Guidelines for the management of patients with atrial fibrillation:areport of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines developed in partnership with the European Society of Cardiology and in collaboration with the European Heart Rhythm Association and the Heart [J].Journal of the American College of Cardiology,2011.e101-e198.
  • 4Jessup M,Abraham WT,Casey DE. 2009 focused update:ACCF/AHA Guidelines for the Diagnosis and Management of Heart Failure in Adults:a report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines:developed in collaboration with the International Society for Heart and Lung Transplantation[J].Circulation,2009.1977-2016.
  • 5Akki A,Zhang M,Murdoch C. NADPH oxidase signaling and cardiac myocyte function[J].Journal of Molecular and Cellular Cardiology,2009.15-22.
  • 6Sedeek M,Hebert RL,Kennedy CR. Molecular mechanisms of hypertension:role of Nox family NADPH oxidases[J].Current Opinion in Nephrology and Hypertension,2009.122-127.
  • 7Cave A. Selective targeting of NADPH oxidase for cardiovascular protection[J].Current Opinion in Pharmacology,2009.208-213.doi:10.1016/j.coph.2008.10.001.
  • 8Dandapat A,Hu CP,Li D. Overexpression of TGFbetal by adeno-associated virus type-2 vector protects myocardium from ischemia-reperfusion injury[J].Gene Therapy,2008.415-423.
  • 9潘莉,谢朝欢.他汀类药物对脑梗死患者血清超敏C反应蛋白的影响及预后评价[J].中国医学文摘(老年医学),2008,17(3):131-133. 被引量:6
  • 10张玉宏,刘万娟,丁珊.丹红联合低分子肝素钙治疗急性脑梗死的临床研究[J].实用心脑肺血管病杂志,2010,18(1):3-5. 被引量:10

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