喹硫平联合氟西汀治疗难治性抑郁症

Control study of fluoxetine combined quetiapine on treating refractory depression

目的:了解喹硫平及氟西汀联合治疗难治性抑郁症的疗效。方法:60例难治性抑郁症患者随机分为两组,一组氟西汀治疗,另一组氟西汀联合喹硫平治疗。采用汉密尔顿抑郁量表(HAMD)评分,以HAMD减分率评定疗效。结果:氟西汀组显效率23.3%,有效率40.0%;喹硫平联合氟西汀组显效率50.0%,有效率73.3%,疗效明显优于氟西汀组(P<0.01)。两组不良反应均较少。结论:喹硫平及氟西汀联合治疗难治性抑郁症可取得较好疗效,安全性好,不良反应少。对于单用抗抑郁药治疗效果欠佳的抑郁症患者可考虑加用非典型抗精神药物。

Objective：To observe the curative effect and safety of fluoxetine combined quetiapine on treating refractory depression.Methods：60 patients with refractory depression were randomly divided into two groups.The study group was treated with fluoxetine combined quetiapine.The control group was treated with fluoxetine only.The treatment courses of the two groups were both eight weeks.The curative effect and safety of the two groups before treatment and after treatment for 1,4,8 weeks were evaluated with HAMD.Results：The HAMD score of study group after treatment for first week was obviously lower than that before treatment and control group（P0.05）,so did for 4 weeks and 8 weeks.The excellence rate and the effective rate in fluoxetine group were 23.3% and 40% respectively,those were 50% and 73.3% in fluoxetine combined quetiapine group,the latter was significantly superior to the former（P0.05）.There were less adverse reactions in both the two groups.Conclusion：Fluoxetine combined quetiapine has better curative effect and high safety with less adverse reactions on treating refractory depression.If single antidepressant has poor effect in treating the patients with depression,adding atypical antipsychotic drugs could be considered.