摘要
目的:探讨多发性骨髓瘤(MM)的细胞形态学、白球蛋白比例(A/G),血清蛋白电泳、血清免疫固定电泳,在疾病诊断中的作用。方法:回顾性分析31例多发性骨髓瘤细胞形态学特点,实验室常用指标和临床特点。结果:31例MM病例中:骨髓涂片中骨髓瘤细胞比例在(10%-20%)的6例(19.4%),骨髓瘤细胞比例在(21%-30%)的2例(6.4%),骨髓瘤细胞比例在(31%-85.5%)的20例(64.5%),骨髓瘤细胞比例〈10%的3例(9.7%);血清蛋白电泳有M蛋白的26例(83.3%);血清免疫固定电泳:IgG型18例(58.1%),IgA型8例(25.8%),轻链型5例(16.1%);白球蛋白比例(A/G)倒置的24例(77.4%)。结论:骨髓细胞形态学检查是诊断MM的主要方法。血清学特点和临床表现对MM的诊断有提示作用,三者需紧密结合。
Objective:Of multiple myeloma(MM) cell morphology,Albumin globulin ratio(A / G),serum protein electrophoresis,serum immunofixation electrophoresis,the role in disease diagnosis.Methods: Retrospective analysis of 31 cases of multiple myeloma cells in morphology,commonly used laboratory indicators and clinical characteristics.Results: 31 cases of MM cases: Bone marrow smears in the proportion of myeloma cells(10%-20%) of 6 patients(19.4%).The proportion of myeloma cells(21% -30%) of the 2 cases(6.4%).The proportion of myeloma cells(31%-85.5%) of the 20 cases(64.5%).The proportion of myeloma cells 10% of the 3 patients(9.7%);Serum protein electrophoresis with M protein in 26 cases(83.3%);Serum immunofixation electrophoresis: IgG type in 18 cases(58.1%),IgA in 8 cases(25.8%),Light chain in 5 cases(16.1%);Albumin globulin ratio(A/G) inversion of the 24 patients(77.4%).Conclusion: Morphological examination of bone marrow cells is the main method of diagnosis of MM's.Serological features and clinical manifestations suggest the diagnosis of MM role,three to be closely integrated.
出处
《中国卫生检验杂志》
CAS
2011年第5期1201-1202,共2页
Chinese Journal of Health Laboratory Technology
关键词
多发性骨髓瘤
细胞形态学
血清蛋白电泳
血清免疫固定电泳
血清白球蛋白比例(A/G)
Multiple myeloma
Cell morphology
Serum protein electrophoresis
Serum immunofixation electrophoresis
The proportion of albumin-globulin serum(A / G)