头孢他啶对ICU病区分离的铜绿假单胞菌体外抗菌活性的变化研究

Analysis the antimicrobial activity of Ceftazidime to Pseudomonas aeruginosa in ICU wards

目的:了解富阳人民医院头孢他啶对ICU分离的铜绿假单胞菌抗菌活性的变迁情况,为临床的抗感染与治疗提供鉴见。方法:用WHONET5软件统计分析富阳人民医院5年铜绿假单胞菌临床分离菌株,用bioLIAISON统计分析头孢他啶累积MIC分布变迁情况,以确定其抗菌活性的变化。结果:铜绿假单胞菌的分离率从2006年2.2%到2010年3.1%;阳性构成比,从2006年9.4%到2010年11.3%;头孢他啶对铜绿假单胞菌的累积MIC值从2006年到2010年向高值漂移,对铜绿假单胞菌的抑菌率(敏感率)2006年-2010年,分别为64.8%,60.2%,58.3%,56.8%和51.9%逐年下降;结论:铜绿假单胞菌在ICU分离率在逐年上升,头孢他啶对ICU分离的铜绿假单胞菌的抗菌活性呈下降趋势,应引起重视,合理使用抗菌药物以降低耐药性已经非常重要。

Objective：To review and analyze the variance of accumulative MIC of Ceftazidime with Pseudomonas aeruginosa in icu wards from 2006 to 2010,to show the tendency of that in our hospital,and to help carrying on the prevention and therapy of infection.Methods： The Pseudomonas aeruginosa in recent five years were analyzed statistically with WHONET 5 software,the accumulative MIC of Ceftazidime were analyzed statistically with bioLIAISON software.Results： The isolation rate of Pseudomonas aeruginosa was increasing in the recent years from 2.2% to 3.1%（2006-2010）.The susceptibility rate to ceftazidime from 2006 to 2010,were 64.8%,60.2%,58.3%,56.8% and 51.9%.The accumulated MIC of Ceftazidime had being rised with a drift to a higher value.Conclusion： The resistance and the isolation rate of Pseudomonas aeruginosa in icu wards had being increased in recent years.We should pay attention to this.How to use the antimicrobialagents to decrease the resistance was very important.