肠易激综合征与抑郁症的关系

Relationship between irritable bowel syndrome and major depression

目的:探讨肠易激综合征(IBS)与抑郁症的关系。方法:运用Zung抑郁自评量表(SDS)和汉密尔顿抑郁量表(HAMD)评分筛选出合并抑郁症的IBS患者48例,随机分为A组和B组,A组予以得舒特、多塞平联合精神心理治疗,B组单用得舒特治疗,治疗8周后再行IBS症状计分、SDS和HAMD表评分。结果:A组患者治疗后IBS症状计分、SDS评分、HAMD评分明显改善,A组总有效率(83.3%),优于B组(25.0%),差异有统计学意义(P<0.01)。结论:对IBS患者行抑郁水平评估,联合抗抑郁、精神心理治疗,可以明显改善IBS症状,提高疗效。

Objective：To investigate the relationship between irritable bowel syndrome（IBS） and major depression.Methods：48 patients with IBS,which scores of Self-Rating Depression Scale（SDS） beyond 40 and Hamilton Rating Scale for Depression（HAMD） beyond 20,were randomly assigned into two groups： group A（treatment group） and group B（control group）.24 cases of group A took oral dicetel 50mg,3 times daily and oral doxepin 25mg,3 times daily combined with psychotherapy.24 cases of group B only took dicetel 50 mg,3 times daily.After 8-week treatment,the scores of IBS,SDS and HAMD were evaluated again and compared between the two groups.Results：The IBS symptom scores,SDS scores and HAMD scores in group A were decreased more obviously than those in group B after 8-week treatment.The total effective rate was 83.3% in the treatment group and 25% in the control group.The group A achieved better effects than the group B with statistical difference（P0.01）.Conclusion：Evaluating the depression level combining the application of antidepressants and psychotherapy on the patients with IBS can remarkably improve IBS symptoms and increase the curative effects.