子痫前期重度患者FⅧ、FⅨ、AT-Ⅲ的测定分析

Detection of FⅧ,FⅨ,AT-Ⅲ of patients with severe pre-eclampsia

目的通过对子痫前期重度患者、正常妊娠妇女凝血功能及肝功能指标检测分析,探讨该疾病血管内皮细胞损伤、凝血系统激活及肝功能受损情况。方法通过使用凝固法,发色底物法,免疫法检测30例正常妊娠足月妇女、25例早发型重度子痫前期、35例晚发型重度子痫前期患者入院未用药前FVIII,FⅨ、AT-III,D-Dimer指标,并采用全自动生化分析仪测定其ALT、AST肝功能指标。结果早发型重度子痫前期组、晚发型重度子痫前期与正常对照组比AT-Ⅲ下降,FⅨ、D-D、ALT、AST升高,且差异具有统计学意义(P<0.01)。结论子痫前期重度尤其是早发型患者存在严重的血管内皮细胞损伤、血液高凝状态,随着病情的发展出现一定程度的肝功能损伤。

Objective：To approach the damage of vascular endothelial cell,the actived state of coagulation and the disfunction of liver of patients with pre-eclampsia.Methods： The levels of clotting factor Ⅷ,Ⅸ,antithrombin Ⅲ,D-dimer were determined by solidification,chromogenic,immunization respectively.and the levels of ALT,AST were measured by auto biochem istry analysator.The venous blood of 30 normal pregnancy women,25 early onest severe pre-eclampsia women,35 late onest severe pre-eclampsia women were collected.Results： The level of AT-Ⅲ of early onest severe pre-eclampsia and late onest severe pre-eclampsia were much lower than that of normal pregnancy group（P 0.01）.The levels of FⅨ,D-D,ALT,AST of them were much higher than those of normal pregnancy group（P 0.01）.Conclusion： Patients with pre-eclampsia have the damaged vascular endothelial cells and the actived state of coagulation,and dysfunction of liver the development of the pathogenetic condition.