高危人流术后立即服用低剂量戊酸雌二醇的临床观察

Clinical observation on the clinical efficacy of immediate intake of low dosage estradiol valerate after high-risk induced abortion

目的:观察高危人工流产术后立即服用低剂量戊酸雌二醇预防宫腔粘连的效果。方法:普通人工流产120例(A组)和高危人工流产360例术后均服用相同抗生素、益母草浸膏1周。将高危人工流产受术者随机分成3组各120例:B组加服低剂量戊酸雌二醇,C组加服高剂量戊酸雌二醇,D组不加服。比较各组术后3个月宫颈、宫腔粘连情况。结果:D组宫腔粘连发生率明显高于A、B、C组(P<0.05),A、B、C组相比,差异无统计学意义(P>0.05)。高危人流B、C、D组的宫颈粘连发生率差异无统计学意义(P>0.05)。结论:普通人流手术后不必要常规行人工周期,高危人工流产术后立即服用低剂量戊酸雌二醇,对预防宫腔粘连有显著效果,值得临床推广应用。

Objective：To observe the effect of immediate intake of low dosage estradiol valerate on prevention of intrauterine adhesion after high-risk induced abortion.Methods：120 cases of normal induced abortion（group A） and 360 cases of high risk induced abortion took the same antibiotic and leonurus cream for one week after abortion surgery.The 360 cases of high risk induced abortion were randomly divided into three groups,120 cases in each group：the cases in group B added low dosage estradiol valerate,the cases in group C added high dosage estradiol valerate,and the cases in group D didn’t add estradiol valerate.The cervical and intrauterine adhesion situations in the four groups were compared at 3 months after abortion surgery.Results：The incidence of intrauterine adhesion in group D was significantly higher than those in group A,group B and group C（P〈0.05）.There was no significant difference among group A,group B and group C（P〉0.05）.And there was no significant difference among group B,group C and group D（P〉0.05）.Conclusion：For the cases receiving normal induced abortion surgery,regular artificial cycle is not necessary;immediate intake of low dosage estradiol valerate after high-risk induced abortion can prevent intrauterine adhesion obviously,which is worthy to be popularized.