口服雌激素、孕激素、避孕药治疗青春期功能性子宫出血的效果

The therapeutic effects of oral administration of estrogen,progestogen and contraceptive in pubertal dysfunctional uterine bleeding

目的:比较口服雌激素、孕激素、避孕药治疗青春期功能性子宫出血的效果。方法:选取北京市海淀医院2006年1月～2010年8月门诊和住院收治的51例青春期功能性子宫出血患者,按照随机对照法分为3组,即雌激素组(15例)、孕激素组(16例)及口服避孕药组(20例)。对3组患者的快速控制出血率、快速完全止血率、完全止血成功率、控制出血时间及完全止血时间进行记录和评价。结果:在快速控制出血、快速完全止血及完全止血成功三方面比较,孕激素组及口服避孕药组明显高于雌激素组(P<0.05);孕激素组及口服避孕药组患者的控制出血时间、完全止血时间明显低于雌激素组(P<0.01)。结论:在治疗青春期功能性子宫出血效果方面,口服孕激素和口服避孕药的效果优于口服雌激素。

Objective：To compare the therapeutic effects of oral administration of estrogen,progestogen and contraceptive in pubertal dysfunctional uterine bleeding.Methods：51 cases with pubertal dysfunctional uterine bleeding were selected from the hospital from January 2006 to August 2010,then they were randomly divided into estrogen group（15 cases）,progestogen group（16 cases） and contraceptive group（20 cases）.The quick control rate of bleeding,quick total hemostasis rate,success rate of total hemostasis,control bleeding time and time of total hemostasis in the three groups were recorded and evaluated.Results：The quick control rate of bleeding,quick total hemostasis rate and success rate of total hemostasis in progestogen group and contraceptive group were significantly higher than those in estrogen group（P〈0.05）.The control bleeding time and time of total hemostasis in progestogen group and contraceptive group were significantly lower than those in estrogen group（P〈0.01）.Conclusion：The effects of oral administration of progestogen and contraceptive are better than that of oral administration of estrogen in treatment of pubertal dysfunctional uterine bleeding.