双黄连粉针中连翘用大孔树脂精制的工艺研究

Refining Technology of Macroporous Resin for Forsythia Suspensa Vahl from ShuangHuangLian Plenting Licensing Injection

目的：采用大孔树脂对双黄连粉针中君药连翘进行精制,优选出最佳的树脂以及洗脱条件。方法：采用吸附、洗脱试验确定精制连翘的最佳树脂,绘制泄漏曲线确定树脂的上样量。结果：双黄连粉针中君药连翘精制的最佳树脂为NKA-9,上样量在5∶4~5∶6（树脂：原药材）的范围内,4BV蒸馏水去杂质,3BV 40%乙醇解吸附。结论：为精制双黄连粉针中君药连翘优选了一套合理稳定的工艺,并为该药二次开发打基础。

Objective： Using macroporous adsorptive resin for Shuanghuanglian plenty licensing injection of forsythia refining,optimizing the best resins and elution requirement.Methods： Adopt adsorption,elution test to determine the best resin,refined forsythia drawing leakage curve to determine the resin on the sample weight.Results： Shuanghuanglian plenty licensing injection in the best forsythia refined resin as NKA-9,the sample weight for 5∶ 4-5∶ 6（resin： original medicinal materials）,within the scope of the 4BV distilled water to impurities,3BV40 % ethanol desorption attached.Conclusion：As refined Shuanghuanglian plenty licensing injection of forsythia there are a set of reasonable selective processes for the solid foundation of the secondary development.