ⅠB～ⅡA期宫颈癌患者的治疗及预后分析

Treatment and the Prognostic Factors Analysis in Patients with Cervix Cancer of Stage ⅠB-ⅡA

目的:探讨ⅠB～ⅡA期宫颈癌治疗方法及预后影响相关因素。方法:选择1999年1月～2004年7月间在内蒙古医学院附属医院收治的ⅠB～ⅡA期宫颈癌患者98例,对其临床、病理资料、治疗方法及预后因素进行回顾性分析,患者随访至2008年12月。结果:随访期内,共20例患者死亡,均死于宫颈癌复发,占20.4%(20/98),2例患者出现疾病进展,占2.04%(2/98)。98例患者5年总生存率为85.7%。单因素分析显示,年龄、宫旁浸润、脉管浸润、淋巴转移与预后明显相关(P<0.05);多因素分析显示,年龄、病理分级、宫旁浸润、淋巴转移、术后放疗因素对宫颈癌的预后有影响(P<0.05)。结论:年龄、病理分级、宫旁浸润、淋巴转移、术后辅助放疗是影响ⅠB～ⅡA期宫颈癌患者预后的独立因素。治疗应根据患者的年龄、病理分级、宫旁浸润、淋巴转移等因素,实施个体化综合性治疗方案,以改善患者的预后及生存质量。

Objective：To study treatment and the prognostic factors in patients with cervix cancer of stageⅠB and ⅡA.Methods： 98 cervix cancer patients of stageⅠB and ⅡA was enrolled,who were operated from January 1999 to July 2004 of the first affiliated hospital of Inner Mongolia Medical college.Study retrospectively the clinical and pathological information,treatment methods and prognostic factors of these patients,who were followed up until December 2008.Results： During the follow-up period,20 patients died of recurrence of cervix cancer（20.4%）.2 patients progressed（2.04%）,5-year survival rate of overall these 98 patients was 85.7%.Single factor analysis manifested that significant correlation was found between the prognosis and age,parametrial invasion,vascular invasion,lymph node metastasis（P0.05）.Multi-factor analysis displayed that the following factors,including age,pathology stage,parametrial invasion,lymph node metastasis,postoperative adjuvant radiotherapy influenced the prognosis of cervic cancer patients（P0.05）.Conclusion： Age,pathology stage,parametrial invasion,lymph node metastasis and postoperative adjuvant radiotherapy were all independent risk factors that effected the prognosis of cervix cancer in stageⅠandⅡ.Individualized comprehensive treatment plan should be taken according to different age,pathology stage,parametrial invasion and lymph node metastasis to improve the patient＇s prognosis and quality of life.