幽门螺杆菌感染与大肠肿瘤的关系

Helicobacter Pylori infection and colorectal neoplasm

目的 探讨幽门螺杆菌（Hp）感染与大肠肿瘤相关性.方法 通过对行同期肠镜检查的329例患者进行14C-尿素呼气试验和Hp粪便抗原检测结果将患者分为腺瘤组、腺癌组和无肿瘤组,分析3组患者的Hp感染率.结果 在无肿瘤组Hp阳性率为51%、腺瘤组65.29%、腺癌组66.10%,大肠腺瘤和腺癌的Hp阳性率与无肿瘤者相比差异有统计学意义（P＜0.05）.感染Hp的大肠腺瘤、腺癌的发现率与无肿瘤者相比差异有统计学意义（P＜0.05）.Hp阳性者大肠腺瘤、腺癌发生相对危险性的比较差异均有统计学意义（P＜0.05）.结论 Hp感染可能增加大肠肿瘤发生的风险.

Objective To investigate the prevalence of Helicobacter Pylori （Hp） infection in patients with colorectal neoplasm.Methods Three hundred and twenty nine patients underwent colonoscopy examination, and also received ^14C urea breath test （^14C-UBT） and stool Hp antigen test （HPSA）. Hp infection rates in patients with adenomatous polyposis coil （APC）, with colorectal cancer （CRC）, and normal subjects were compared. Results Compared to normal subject, the Hpositive rates in APC group and in CRC group were significantly higher （65.3% vs 51.0%, P〈0.05 and 66.1% vs 51.0%, P〈0.05）. The relative risk of Hp infection for APC was 1.8072 （95% C1：1.0509-3.1078, P〈0.05）, for CRC was 1.8735 （95% C1：1.0845-3.2365, P〈0.05）. Conclusion Helicobacter Pylori infection might be associated with the increased risk of colorectal neoplasm.