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ATP-TCA法对胃癌常用化疗药物体外作用的评价

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摘要 胃癌是最常见的消化系统恶性肿瘤,位列全球第四大常见肿瘤,占全球癌症死亡原因的第二位.术前、术后化疗是胃癌的重要辅助治疗方式.近年来,各大制药企业不断研发新的抗癌药物,临床上肿瘤化疗的应用更加广泛合理,化疗药物在以手术为主的综合治疗中占有重要地位.术前化疗可使原发癌缩小,为手术切除创造有利条件,降低肿瘤细胞活力,消灭微波转移灶,提高综合治疗后患者的长期生存率.但化疗药物的选择和确定尚缺乏统一的标准,存在盲目性、随意性,无效药物可对人体造成损害,从而降低患者的生存质量.基于三磷酸腺苷生物荧光法（ATP-TCA）检测肿瘤体外的药物敏感性,是近年发展起来的对恶性肿瘤具有较高可评估率的方法,其有助于临床医师确定化疗药物组合及制定个体化化疗方案,减少治疗开支,降低药物的不良反应,提高化疗的有效率.本研究采用此方法对85例胃癌标本进行检测,比较7种常用化疗药物和3种联合化疗方案的敏感性,以期为临床胃癌化疗提供参考依据.
作者 段百芸 李克强
机构地区 宁波市第二医院肿瘤外科
出处 《浙江医学》 CAS 2011年第5期690-692,共3页 Zhejiang Medical Journal
关键词 化疗药物 胃癌标本 ATP-TCA法 体外作用 消化系统恶性肿瘤 三磷酸腺苷生物荧光法 联合化疗方案 药物敏感性
分类号 R730.53 [医药卫生—肿瘤]
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参考文献10

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浙江医学
2011年 第5期

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