摘要
目的 探讨核因子-κB（NF-κB）在乳腺癌组织中的表达及其临床意义.方法 采用免疫组化Envision法检测87例乳腺癌及癌旁乳腺组织中NF-κB（P65）的表达状况.结果 NF-κB（P65）在乳腺浸润性导管癌中的表达与组织学分级（x2=5.869,6.716,均P＜0.05）、淋巴结转移（x2=6.594,P＜0.05）、TNM分期（x2=9.408,P＜0.05）和人表皮生长因子受体-2（HER-2）的状态（x2=6.228,P＜0.05）均有显著相关性;与肿瘤直径的大小、年龄以及雌激素受体（ER）、孕激素受体（PR）的状态无明显相关性.结论 NF-κB（P65）的表达可能是乳腺浸润性导管癌预后较差的危险因素.
Objective To explore NF-κB（P65）expression in breast cancer and its clinical significance.Methods Immunohistochemical staining was used to examine the expression of NF-κB（P65）and its relationship with related elinicopathological factors were analyzed in eighty-seven IDC（invasive ductal cancinoma）.Results NFκB（P65）expression was significantly correlated with lower tumor grading,maxilary lymph node metastasis,later TNM styng and HER-2 positive（all P＜0.05）,but not with tumor size,age of the patient and the state of ER、PR.Conclusion NF-κB（P65）should be risk factors of poor prognosis in IDC.
出处
《中国基层医药》
CAS
2011年第10期1317-1318,共2页
Chinese Journal of Primary Medicine and Pharmacy
关键词
乳腺癌
核因子-ΚB
免疫组织化学
Breast neoplasms
Nuclear factor-κB
Immunohistochemistry
