布地奈德雾化吸入治疗新生儿气管插管后喉头水肿的临床观察

Studs on effect of nebulised budesonide in treatment of neonatal laryneal edema caused by mechanical ventilation

目的 探讨采用布地奈德雾化治疗新生儿气管插管后喉头水肿的疗效.方法 43例接受气管插管的新生儿随机分为观察组（23例）：拔管前30 min雾化吸入布地奈德雾化溶液;对照组（20例）：拔管前静脉注射地塞米松,拔管后每1小时雾化吸入肾上腺素.记录各组喘鸣或声嘶及气促消退天数及处理后的动脉血氧分压（PaO2）和动脉血二氧化碳分压（PaCO2）.结果 观察组喉头水肿消退时间（10.26±4.01）h,气促缓解时间（1.63±0.55）d,明显短于对照组的（14.20±5.58）h,（2.05±0.58）d（P＜0.05）.两组患儿治疗后血气指标差异无统计学意义（均P＞0.05）.结论 布地奈德雾化吸入治疗新生儿气管插管后喉头水肿起效更快,优点更多.

Objective To discuss the clinicd effect of using nebulised budesonide to treat neonatal laryneal edema caused by mechanical ventilation.Methods 43 newborns with mechanical ventilation were included in this study and divided into two groups：The Observational group（23 newborns）were treated with nebulised budesonide right before excubation once and three times after that,and the control group（20 newborns）were treated with dexamethasone once right before excubation and nebulised adrenine after that for three times.Comparisons were made between two groups about dismissing time of wheeze or hoarseness,tachypnea,PaO2 and PaCO2.Results Observational group：dismissing time of wheeze or hoarseness was（10.26±4.01）hours,dismissing time of tachypnea was（1.63±0.55）days,which was shorter than that of control group[（14.20±5.58）hours/（2.05±0.58）days],P＜0.05）.PaO2 and PaCO2 of two groups had no statistical difference（P＞0.05）.Conclusion Nebulised budesonide was effective in treatment neonatal laryneal edema caused by mechanical ventilation,using.