妊娠期糖尿病患者血清超敏C反应蛋白与胰岛β细胞功能的相关性研究

Investigation on correlation between serum hypersensitivity-CRP and β-cell function in patients with gestational diabetes mellitus

目的 探讨妊娠期糖尿病（GDM）患者血清超敏C反应蛋白（hs-CRP）与胰岛β细胞功能的关系.方法 选择60例GDM孕妇作为观察组（GDM组）,同时选择30例糖耐量正常的孕妇作为对照组（NGT组）,测定hs-CRP水平,同时计算稳态模型胰岛素抵抗指数（HOMA-IR）和胰岛素分泌指数（HOMA-β）.结果 GDM组的hs-CRP和HOMA-IR显著高于NGT组（P＜0.01）,而HOMA-β显著低于NGT组（P＜0.05）.hs-CRP与年龄、孕前BMI、筛查时BMI、空腹血糖（FBG）、空腹胰岛素（Flns）和HOMA-IR显正相关（r=0.222,0.649,0.862,0.923,0.935,0.941,P＜0.05或P＜0.01）,与HOMA-β呈负相关（r=-0.872,P＜0.01）.多元逐步回归分析显示,HOMA-IR和HOMA-β是影响hs-CRP最为显著的因素.结论 GDM 患者血清hs-CRP水平明显升高与胰岛素抵抗（IR）及胰岛细胞分泌功能密切相关,可能参与GDM的发生和发展.

Objective To explore the correlation between serum hs-CRP and β-cell finction in patients with gestational diabetes mellitus（GDM）.Methods The levels of hs-CRP in 60 patients with GDM（GDM group）and 30pregnant women with normal glucose tolerance（NGT group）were detected.Insulin resistance was assessed by the homeostasismodel insulin resistance index（HOMA-IR）,Insulin secretion by the homeostasis β-cell funetiOn index（HOMA-β）.Results The levels of hs-CRP and HOMA-IR were higher in GDM group than in NGT group.There was significant difference between two groups（P＜0.01）;HOMA-β was lower in GDM group than in NGT group,there was significant difference between two groups（P＜0.05）.The level of hs-CRP was correlated with age,pre-pregnant bodymass-index（BMI）,screening BMI,fasting blood glucose（FBG）,fasting insulin（Fins）,and HOMA-IR（r=0.222,0.649、0.862、0.923、0.935、0.941,P＜0.05 or P＜0.01）,but was inversely related with HOMA-β（r=-0.872,P＜0.01）.Multiple stepwise regression analysis indicated that HOMA-IR and HOMA-β was the most important effect factors of hs-CRP.Conclusion The level of hs-CRP increased in women with GDM.which was related to insulin resistance（IR）and insulin secretion,and it maybe participate in the pathogenesis of GDM.