综合干预对特应性体质婴幼儿生活质量的影响

Research on the influence of comprehensive intervention on the quality of life of infants and young children with atopic constitution

目的 探讨综合干预对改善特应性体质婴幼儿生活质量的影响.方法 采用随机、双盲法对106例6个月至1岁有特定遗传背景且患有湿疹、喘息的特应性体质患儿开展过敏原检测及综合干预对照研究,18个月后比较症状发作、免疫功能测定情况.结果 18个月后治疗组血清IgG和IgA升高（均P＜0.05）,喘息、湿疹发作明显减少（均P＜0.01）,睡眠、情绪改善明显（均P＜0.05）;牛奶、鸡蛋是婴幼儿最常见的过敏原.结论 特应性体质与环境因素是变应性疾病的危险因素,婴幼儿期是影响儿童是否发生变应性疾病的关键时期,及早采取干预措施可降低儿童过敏性疾病的发生,改善特应性体质婴幼儿生活质量.

Objective To investigate the influence of comprehensive intervention on improving the quality of life of idiosyncratic infants and young children.Methods A control study Was conducted on 106 idiosyncratic patients aged 6 months to 1 year with specific genetic background,eczema and wheezing under allergen test and comprehensive intervention via a randomized double-blind method.The onset of symptoms and measurement of immunological function were compared after 18 months.Results Serum IgG and IgA increased（all P＜0.05）,wheezing and eczema attacks decreased significantly（all P＜0.01）,sleep and emotion also improved significantly in the treatment group after 18 months（all P＜0.05）.Milk and eggs were the most common allergen for infants and young children.Conclusion Idiosyncrasy and environmental factors were risk factors for allergic diseases.Early childhood was a critical period influencing the occurrence of allergic diseases in children.Early intervention could reduce the incidence of allergic diseases in children and improve the quality of life of idiosyncratic infants and young children.