单采血小板捐献者血清铁蛋白与部分血常规指标的相关性分析

Correlation Analysis Between Serum Ferritin and Some Blood Routine Indexes in Platelet Pheresis Donors

目的 分析单采血小板捐献者血清铁蛋白（serum ferritin,SF）与部分血常规指标的相关性,为筛选对SF含量有预示作用的血常规指标提供参考.方法 以2010年10月至2011年2月在本血站献血的111例单采血小板捐献者为研究对象,采用酶联免疫吸附法（enzyme-linked immunosorbent assay,ELISA）检测其SF含量,采用血细胞分析仪进行血常规检测,采用SPSS 17.0统计学软件包分析SF与红细胞（red blood cell,RBC）、白细胞（white blood cell,WBC）、血小板（platelet,PLT）、血红蛋白（hemoglobin,Hb）、红细胞平均体积（mean corpusular volume,MCV）、红细胞分布宽度（red blood cell volume distribution width,RDW）、平均血小板体积（mean platelet volume,MPV）、大血小板比例（platelet-large cell ratio,P-LCR）及血小板分布宽度（platelet distribution width,PDW）之间的相关性.结果 单采血小板捐献者的SF含量为（66.81±36.63）μg/L,所有捐献者的RBC、Hb、WBC及PLT值均在正常值范围内,SF与RDW及PLT之间呈负相关关系,r=0.347,-0.315;P=0.001,0.003,RDW与PLT之间呈正相关关系,r=0.265,P=0.013.结论 RDW及PLT的检测结果对SF含量有预示作用.对于RBC和Hb检测结果正常的捐献者,应重点关注RDW和PLT检测值,可有助于发现隐匿性缺铁捐献者.

Objective To analyze the correlations between serum ferritin （SF） and some blood routine indexes in plateletpheresis donors, so as to screen blood routine indexes which can indicate SF level.Methods 111 plateletpheresis donors from October 2010 to February 2011 in Foshan central blood station were selected. These donors＇ SF and blood routine indexes were measured by enzyme-linked immunosorbent assay （ELISA） and blood cell analyzer respectively. SPSS statistics 17. 0 was used to analyze the correlations between SF and red blood cell （RBC）, white blood cell （WBC）, platelet （PLT）, hemoglobin （Hb）, mean corpuscular volume （MCV）, red blood cell distribution width （RDW）, mean platelet volume （MPV）, platelet-large cell ratio （P-LCR） and platelet distribution width （PDW）. Results SF level of plateletpheresis donors was （66. 81 ±36. 63） μg/L and all the donors＇ RBC, Hb, WBC and PLT were within the normal range. RDW and PLT were negatively correlated to SF （r= - 0. 347, and -0. 315 respectively; P〈0. 05）, RDW was positively correlated to PLT （r=0. 265, P〈0. 05）. Conclusion RDW and PLT can indicate SF level in plateletpheresis donors. Paying extra attention to RDW and PLT can contribute to search for latent iron deficiency donors whose RBC and Hb are within the normal range.