摘要
目的:探讨宫颈癌与宫颈上皮内瘤变(CIN)组织中mPGES-1和Cox-2的表达及意义。方法:采用实时荧光定量PCR法,分别检测我院手术切除宫颈癌组织和各级CIN组织中mPGES-1和COX-2的mRNA表达。结果:宫颈癌与CIN组织中mPGES-1和COX-2的表达量显著增高,分别是正常组织的110倍和25倍,两者的mRNA表达量和肿瘤的病理类型或分级相关,低分化的肿瘤组织表达量高。结论:mPGES-1mRNA在宫颈癌与宫颈上皮内瘤变组织中显著高于良性组织,并且和组织病理类型、分级有关,和COX-2表达呈直线正相关。这对宫颈癌及宫颈上皮内瘤变的诊断及治疗均有重要意义。
Objective：To investigate the cervical cancer and cervical intraepithelial neoplasia tissue mPGES-1 expression with pathological characteristics and the relationship between cell differentiation and analysis of mPGES-1 and COX-2 relevance. Method： Real-time fluorescence quantitative PCR method,were used to detect cervical cancer surgery in our hospital and all levels of cervical intraepithelial neoplasia tissue mPGES-1 and COX-2 mRNA,analysis of mPGES-1 and COX-2 related as well as the type of pathology,classification relationship. Result：The cervical cancer and cervical intraepithelial neoplasia tissue mPGES-1 and COX-2 expression was significantly increased, respectively, 110 times the normal tissue and 25 times, both mRNA expression and tumor histological type or grading associated with low differentiation and malignant tumor tissue with high expression of high. In the lesions of mPGES-1 and COX-2 expression was positive correlation. Conclusion：mPGES-I in mRNA in cervical intraepithelial neoplasia and cervical tissues were significantly higher than benign organizations, and the patho- logical type,grading, and COX-2 expression was positive correlation. This study has important clinical significance for cervical cancer and cervical intraepithelial neoplasia diagnosis and treatmenl of the develonment of new drugs
出处
《现代妇产科进展》
CSCD
北大核心
2011年第5期358-360,共3页
Progress in Obstetrics and Gynecology
