CYP1A1基因MspⅠ位点多态性与子宫肌瘤易感性的研究

Correlation of CYP1A1 MspⅠ polymorphism with the susceptibility of the uterine leiomyoma.

目的:探讨细胞色素P450(cytochrome P450,CYP)1A1基因MspⅠ位点多态性与鲁北地区汉族女性子宫肌瘤的关系。方法:以病例-对照的研究方法,采用PCR-RFLP方法检测了123例子宫肌瘤患者和123例匹配对照者的CYP1A1基因MspⅠ位点的基因多态性。应用Logistic回归等方法分析基因多态性与子宫肌瘤的关系。结果:(1)CYP1A1基因MspⅠ位点的基因型在子宫肌瘤组与对照组中分布的差异无统计学意义(P=0.927);(2)杂合型(T/C)和突变型(C/C)与野生型(T/T)在子宫肌瘤组与对照组的分布差异均无统计学意义(P=0.738,P=0.947);(3)合并杂合型(T/C)和突变型(C/C)与野生型(T/T)比较,在子宫肌瘤组与对照组分布的差异无统计学意义(P=0.925)。结论:CYP1A1MspⅠ等位基因多态性与鲁北地区汉族女性子宫肌瘤的易感性无显著相关性。

Objective：To study of the relationship between CYP1A1 genetic polymorphism and uterine leiomyoma in Northern QiLu,about Han people. Methods：Msp I genotypes of CYP1A1 gene were detected with the methods of PCR-RFLP a case-control study,including 123 cases of uterine leiomyoma and 123 cases as controls. Multivariate logistic regression analysis was used to estimate uterine leiomyoma risk associated with environmental exposures by SULT1A1 genotype. Results：（ 1 ）There was no significant correlation between uterine leiomyoma group and control group in Msp I polymorphism（ P = 0. 927 ）. （2）Contrast with T/T genotype,T/C and C/C, the difference between the case and control group all were no significant （ P = 0. 738, P = 0. 947, respectively）. （ 3 ） Contrast with T/T genotype, merging T/C and C/C, the difference between the case and control group was no significant（ P = 0. 925 ）. Conclusions： The results do not imply that CYP1A1 polymorphism of Msp I is associated with susceptibility of uterine leiomyoma, in Northern OiLu. about Han people.