食物不耐受与儿童过敏性紫癜的相关性

Correlation between food intolerance and Henoch-Sch6nlein purpura in children

目的探讨食物不耐受与儿童过敏性紫癜的相关性及不耐受食物禁食或轮替疗法对过敏性紫癜患儿的疗效。方法ELISA法检测40例过敏性紫癜患儿血清14种食物特异性IgG浓度及相关生化指标，同时进行3个月不耐受食物禁食或轮替疗法，观察疗效。结果过敏性紫癜患儿食物不耐受阳性率为92．5％，鸡蛋的阳性率最高，其次为西红柿、牛奶、鳕鱼等。食物不耐受种类在男女、城乡分布间差异无统计学意义（t=1．053，P=0．315；t=1．388，P=0．193），但不同年龄间差异有统计学意义（t=2．257，P=O．045）。食物不耐受累计敏感度与血清IgG浓度无直线相关（t=0．793，P：0．445）。紫癜性肾炎患儿食物不耐受与其肾脏病理中免疫复合物沉积无相关（r=一0．262，P=0．387）。不耐受食物禁食或轮替疗法有效率为95％。结论儿童过敏性紫癜的发生和食物不耐受有密切关系。不耐受食物中以鸡蛋最为多见。不耐詈食物禁食或轸替疗法对大部分过敏忡紫癜患儿有效。

Objective To investigate the correlation between food intolerance and Henoch-Schonlein purpura （HSP） in children and the efficacy of food forbidden or alternative therapy. Methods The levels of IgG against several common food in serum obtained from 40 children with HSP were measured by ELISA. The efficacy of food forbidden or alternative food therapy was assessed after 3 months. Results Total positive rate of serum food-intolerant IgG antibodies in HSP children was 92.5%. Among these 14 intolerant foods, the positive percentage of egg was the highest （33.8%）, followed by tomato （14.9%）, milk （13.5%） and morrhua （12.2%）. Significant differences of the sort and degree of food intolerance existed among different age groups （t=2.257, P=0.045）, but not between boys and girls （t=1.053, P=0.315）, city and countryside （t= 1.388, P=0.193）. There was no linear correlation between total food intolerance and serum IgG level （t=0.793, P=0.445）. Food intolerance had no direct relation to immune complex deposition in kidneys of HSP nephritis （r =-0.262, P =0.387）. The efficacy of adjusting diet was 95%. Conclusions HSP is closely related to food intolerance. Egg is the most common intolerant food. Food forbidden or alternative therapy shows acceptable efficacy in the treatment of most HenochSch/inlein purpura children.