胚胎着床过程中的STAT3调控网络

Molecular Network of STAT3 During Embryo Implantation

信号转导和转录激活因子3(signal transducer and activator of transcription 3,STAT3)为STAT家族的一员,抑制小鼠子宫中的STAT3活性会导致胚胎着床受阻,表明STAT3在胚胎着床过程中发挥重要的作用。细胞因子LIF和IL-11主要通过活化STAT3在胚胎着床过程中发挥关键作用。越来越多的证据表明,HB-EGF、VEGF和前列腺素等也能通过活化STAT3,在着床过程中发挥重要作用。另外,HIF1-α、COX2、p53等很多着床相关基因都受STAT3调节。miR-21也是STAT3的下游基因。STAT3与着床相关基因之间的相互调节形成了一个复杂的分子网络,在胚胎着床过程中可能发挥至关重要的作用。

Signal transducer and activator of transcription 3 （STAT3） is a key transcription factor. The inhi- bition of STAT3 activity in mouse uterus results in reduced implantation, suggesting that STAT3 plays an important role during embryo implantation. LIF and IL-11 are well-known implantation-related cytokines and can activate STAT3. Recent evidences show that STAT3 can also be activated by HB-EGF, VEGF and prostaglandin, which play profound roles during embryo implantation. Many important genes during embryo implantation, such as HIFI-a, COX-2 andp53, can be regulated by STAT3. miR-21 is also a downstream gene of STAT3. The interactions between STAT3 and the implantation-related genes form a complicated network, which may be critical for embryo implanta- tion.