期刊文献+

Thl7细胞/调节性T细胞平衡与类风湿性关节炎 被引量:1

原文传递
导出
摘要 类风湿性关节炎(RA)是一种自身免疫性疾病,它的基本病理改变为关节滑膜慢性炎症形成侵袭性血管翳,破坏软骨、骨与周围组织。大量的临床和基础研究表明T淋巴细胞亚群的紊乱在RA关节局部的炎症发展和全身免疫反应过程中发挥的重要作用,当动态平衡被破坏和免疫系统被激活时,机体易得自身免疫病。有效的免疫稳态依赖于许多因素的平衡,包括辅助性T(h)细胞活性和Treg细胞的抑制。
出处 《中国骨与关节损伤杂志》 2011年第5期478-480,共3页 Chinese Journal of Bone and Joint Injury
基金 国家自然科学基金(30860258)
  • 相关文献

参考文献18

  • 1Huang W, O'Keefe RJ,Schwarz EM.Exposure to receptor-activator of NFKB ligand renders pre-osteoclasts resistant to IFN-γby inducing terminal differentiation.Arthritis Res,2002,5:49-59.
  • 2Koshy P,Henderson N,Logan C,et al.Interleukin 17 induces cartilage collagen breakdown: novel synergistic effects in combination with proinflammatory eytokines.Ann Rheum Dis, 2002,61 (8) .704 - 713.
  • 3Park H ,Li Z,Yang XO,et al.A distinct lineage of CD4 T ceils regulates tissue inflammation by producing interleukin 17.Nat Immunol, 2005,6(11) : 1133-1141.
  • 4Sakaguehi S,Sakaguchi N,Asano M,et al.Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor alpha-chains (CD25).Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases.Immunol, 1995,155(3):1151-1164.
  • 5Zhou L,Lopes JE,Chong MM,et al.TGF-beta-induced Foxp3 inhibits T(H)17 cell differentiation by antagonizing RORgammat function.Nature, 2008,453 : 236-240.
  • 6Veldhoen M, Hocking RJ,Atkins C J, et aI.TGF beta in the context of an inflammatory cytokine milieu supports de novo differentiation of IL- 17 producing T cells. Immunity, 2006,24(2) : 179 - 189.
  • 7Acosta-Rodriguez EV,Napolitani G,Lanzavecchia A,et al.Interleukins 1 beta and 6 but not transforming growth factor-beta are essential for the differentiation of interleukin 17-producing human Thelper cells.Nat lmmunol,2007,8(9) :942-949.
  • 8Yen DJ,ehenny H,Scheerens F,et al.IL-23 is essential for T cellmedicated colitis and promotes inflammation via IL-17 and IL-6.clin Invest, 2006,116(5) : 1310- 1316.
  • 9Yang L,Anderson DE,Baeeher-Allan C,et al.IL-21 and TGF-beta are required for differentiation of human T (H)17 cells.Nature, 2008,454:350-352.
  • 10LI J,SHEN W,KONG K,et al.Intedeukin-21 induces T-cell activation and proinflammatory eytokine secretion in rheumatoid atthritis.Immunol, 2006,64(5) :515-522.

同被引文献23

引证文献1

二级引证文献12

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部