摘要
一直以来,鼠疫菌的研究多围绕致病机制、疫苗效果评价及鼠疫治疗方案选择展开,而合理有效的鼠疫动物模型正是这些实验研究的基础与前提。研究者构建了包括小鼠、豚鼠及非人灵长类模型在内的多种动物模型,而这些模型也为人类认识、防御及治疗鼠疫菌提供了帮助,特别是一些经典动物模型沿用至今。但随着研究的深入,有些动物模型由于存在某种问题而逐渐被淘汰。本文就鼠疫菌动物模型构建以来,不同模型的优势与不足及其应用展开综述,以期为研究者提供参考。
The research on Yersinia pestis greatly focuses on the pathogenetic mechanism, vaccines and treatments. Effective animal models of plague are the basis of these researches. Numerous types of animal models of plague have been developed, including mice, guinea pigs and non-human primates, etc. , and they are useful for understanding, defending and treating this disease. Some classic models are still used at present for different purposes, however, others were discarded because of certain problems. The advantages and disadvantages of different animal models of plague are summarized and discussed in this review.
出处
《中国实验动物学报》
CAS
CSCD
2011年第2期161-171,共11页
Acta Laboratorium Animalis Scientia Sinica
基金
中国科学院病原微生物与免疫学重点实验室开放课题资助(No.2009CASPMI-001)
关键词
鼠疫菌
模型
动物
致病机制
疫苗
Yersinia pestis
Animal model
Pathogenetic mechanism
Vaccine
Treatment
