摘要
背景与目的:手术难以真正彻底切除脑胶质瘤,术后放射治疗已成为常规。本文回顾性分析胶质瘤患者术后放射治疗的疗效,探讨影响放射治疗胶质瘤预后的因素。方法:对资料完整的75例胶质瘤患者进行回顾性分析。其中低分级胶质瘤28例,高分级胶质瘤40例,未明确分级的7例。手术全切65例,次全切5例,单纯活检5例。术后接受放射治疗的中位时间为35天,其中16例采用60Coγ射线,59例采用直线加速器光子线和电子线混合线束。Kaplan-Meier法计算生存率,Cox比例风险模型进行预后的多因素分析。结果:低分级胶质瘤的1、3、5年生存率分别为92.0%、66.9%、61.7%;高分级胶质瘤的1、3、5年生存率分别为76.9%、38.0%、22.4%。年龄<40岁、低分级胶质瘤、手术全切肿瘤、放疗剂量≥60Gy的患者预后较好。结论:年龄、病理分级、手术切除程度、放疗剂量是影响放射治疗胶质瘤预后的重要因素。
BACKGROUND OBJECTIVE： Radiation therapy is an effective treatment for glioma.In this study,we retrospectively analyzed the outcomes of glioma treated by postoperative radiotherapy and the prognostic factors.METHODS： Clinical data of 75 evaluable glioma patients were studied retrospectively.Of 75 patients,28 had low-grade gliomas,40 had high-grade gliomas and 7 were ungraded.Sixty-five patients received grossly total resection,5 had subtotal resection,whereas 5 had biopsy only.The median duration between opration and radiotherapy was 35 days.Sixteen patients received Colbaltγ-ray beam radiation,and 59 were treated with mixed photon and electron beam using the linear accelerator.The cumulative survival rate and prognostic factors were analyzed and compared with the Kaplan-Meier method and Cox proportional hazard model.RESULTS： The 1-,3-,and 5-year cumulative survival rates of patients with low grade gliomas were 92.0 %,66.9%,61.7 % respectively,as compared with 76.9%,38.0%,22.4% for those with high grade gliomas.Univariate analysis showed that age 40 years,low pathological grade,grossly total tumor resection,radiation dose≥60Gy predicted better survivals.CONCLUSION： Patient＇s age,tumor histology,extent of resection and radiation dose are related to survival.
出处
《中国神经肿瘤杂志》
2011年第1期39-42,共4页
Chinese Journal of Neuro-Oncology
