左旋氨氯地平对血压昼夜节律的影响

Levaml odipine besylate on circadian rhythm of blood pressure

目的探讨高血压患者不同时间服用左旋氨氯地平对异常血压昼夜节律的影响。方法对符合条件的59例原发性高血压患者进行动态血压监测,分为杓型组(n=21)和非杓型组(n=38),将38例非杓型组高血压患者分为左旋氨氯地平晨起服药组(n=21)和晚上服药组(n=17),剂量2.5 mg/d,治疗8周后再次进行动态血压监测。结果晨起服药组和晚上服药组平均白昼收缩压(dSBP)、白昼舒张压(dDBP)、夜间收缩压(nSBP)、夜间舒张压(nDBP)水平较治疗前下降(P<0.05);两种服药方法对dSBP、dDBP的降压作用差异无统计学意义(P>0.05),而对nSBP、nDBP的降压作用差异有统计学意义(P<0.05)。晚上服药组对非杓型高血压的纠正率高于晨起服药组(P<0.05)。结论晚上服用左旋氨氯地平能较好的纠正夜间高血压,使非杓型血压转变为杓型血压,更好的保护靶器官。

Objective： To observe the effect of levaml odipine besylate taken at different times on blood pressure in hypertensive patients with abnormal circadian rhythm.Methods： Fifty-nine hypertensive patients,whose ambulatory blood pressure was monitored,were divided into the dipper group（n=21） and the non-dipper group（n=38）.The group of 38 patients with non-dipper hypertensive patients were also divided into Levamlodipine morning medication group（n=21） and evening medication group（n=17）,with the dose of 2.5mg/d.Ambulatory blood pressure was monitored again after 8 weeks treatment.Results： The mean daytime systolic blood pressure of morning medication（dSBP）,daytime diastolic blood pressure（dDBP）,nighttime systolic blood pressure（nSBP）,nighttime diastolic blood pressure（nDBP） levels were（143.11±5.17）mmHg,（75.16±7.11）mmHg,（126.12±5.18）mmHg,（71.16±5.16）mmHg before the treatment,but decreased after treatment（129.10±6.16）mmHg,（73.16±7.10）mmHg,（121.11±9.12） mmHg,（63.13±3.17） mmHg respectively.Blood pressure levels before and after treatment were statistically significantly different.Conclusion： Levamlodipine taken at night is good in correcting night high blood pressure so that non-dipper blood pressure can be turned into dipper blood pressure for better protection of target organs.