摘要随着人民生活水平的日益提高,我国居民饮食结构有了全面的改善,但也导致了糖尿病发病率居高不下。糖尿病成为继心脑血管疾病和肿瘤之后危害人类健康的"第三杀手"。自20世纪末以来,人们对内源性胰高血糖素样肽-1(glucagon like pep-tide-1,GLP-1)的结构、生理功能等进行了深入研究,现对GLP-1及其类似物的最新研究进展作一综述。
1Rowland KJ,Brubaker PL.Life in the crypt:a role for glucagon-like peptide-2[J].Mol Cell Endocrinol,2008,288(12):63-70.
2Brubaker PL,Drucker DJ.Minireview:glucagon-like peptides regulate cell proliferation and apoptosis in the pancreas,gut,and central nervous system[J].Endocrinology,2004,145(6):2653-2659.
3Dennis MS,Zhang M,Meng YG,et al.Albumin binding as a general strategy for improving the pharmacokinetics of proteins[J].J Biol Chem,2002,277(38):35035-35043.
4Vahl TP,Tauchi M,Durler TS,et al.Glucagon-like peptide-1 (GLP-1) receptors expressed on nerve terminals in the portal vein mediate the effects of endogenous GLP-1 on glucose to lerance in rats[J].Endocrinology,2007,148(10):4965-4973.
6De Heer J,Hoist JJ.Sulfonylurea compounds uncouple the glucose dependence of the insulinotropic effect of glucagon-like pep-tide 1[J].Diabetes,2007,56:438-443.
7Drucker DJ.The biology of incretin hormones[J].Cell Metab,2006,3:153-165.
8Farilla L,Bulotta A,Hirshberg B,et al.Clucagon-like peptide 1 inhibits cell apoptosis and improves glucose responsiveness of freshly isolated human islets[J].Endocrinology,2003,144:5149-5158.
10DruckerDJ,Nauck MA.The incretin system:glucagon-like peptide-1 receptor agonists and dipeptidyl peptidase-4 inhibitors in type 2 diabetes[J].Lancet,2006,368(11):1696-1705.