院前急救与住院救治过程中使用尿激酶溶栓治疗急性心肌梗死的效果研究

Effect of thrombolytic therapy by Urokinase in acute myocardial infarction on omparative first-aid and hospitalized

目的探讨使用尿激酶院前急救与住院溶栓治疗急性心肌梗死(AMI)的不同疗效,并探讨院外溶栓治疗AMI的可行性。方法选择本院救治的90例AMI患者,先期确诊行院前溶栓组44例,入院后溶栓组46例。院外救治组诊断AMI后立即给尿激酶150万U静脉点滴,同期住院后确诊的46例按上述方法立即溶栓。结果确诊后溶栓时间:院外急救组为(1.40±0.35)h,院内溶栓组为(2.51±1.55)h。治疗后冠状动脉总再通率:院前溶栓组80.9%(33/42),2例死亡;住院溶栓组70.5%(31/44),2例死亡(P<0.05)。结论入院前早期溶栓治疗AMI患者可以增加冠状动脉的再通率,安全可行,值得提倡。

Objective：To investigate the effect of thrombolytic therapy by Urokinase in acute myocardial infarction on omparative first-aid and hospitalized,and to explore the feasibility,safety of the pre-hospital thrombolytic therapy in patients with AMI.Methods：Ninety cases of AMI patients were divided into groups of 44 cases of pre-hospital thrombolysis and the hospital thrombolytic group of 46 cases after admission.The first-aid treatment received intravenous Urokinase 1.5 mg immediately after the diagnosis,and 46 cases of hospitalized patients had thrombolytic therapy immediately in hospital by the above method.Results：After diagnosis of AMI,thrombolytic time was（1.40±0.35） hours in the first-aid thrombolysis group,and（2.51±1.55） hours in the hospital thrombolysis group.The total coronary artery patency rate was 80.9% in the pre-hospital thrombolysis group（33/42）,and there were 2 deaths;the hospital thrombolysis group was 70.5%（31/44）,and there were 2 deaths（P0.05）.Conclusion：The pre-hospital thrombolysis in AMI patients takes significantly shorter time to start thrombolysis,and coronary artery patency rate increases,so it is feasible and safe.