前列腺增生症合并的前列腺炎症的病因分析

RISK FACTORS FOR PROSTATIC INFLAMMATION EXTENT OR INFECTION IN BENIGN PROSTATIC HYPERPLASIA

目的:研究经尿道前列腺电切术(trans urethral resection of prostate,TURP)手术治疗的前列腺增生症(cbenign prostatic hyperplasia,BPH)病人前列腺炎症的危险因素。方法:纳入在四川大学华西医院行TURP的BPH病人60例,采用Logistic回归方法分析尿白细胞异常、前列腺感染、前列腺液补体C3浓度、前列腺液SIgA浓度、前列腺每克组织SIgA含量、术前经尿道保留尿管和年龄是否是前列腺炎症的危险因素;结果:尿白细胞异常、前列腺感染、前列腺液补体C3浓度是前列腺炎症程度的危险因素。结论:本研究提示补体系统的激活、前列腺感染、尿路感染与BPH病人前列腺炎症有关。

Objective：To investigate the risk factors for prostatic inflammation extent in patients with benign prostatic hyperplasia（BPH） undergoing trans urethral resection of the prostate（TURP） so as to manage prostatic inflammation more efficiently.Methods：Sixty patients with BPH undergoing TURP in West China Hospital of Sichuan University were studied.Prostate fluid（PF） was collected for the measurement of secretory IgA（SIgA） and complement 3（C3）.Prostate tissue were collected for testing bacterial 16S rDNA by real-time PCR and examining SIgA in the tissue and examining the inflammation.The possible clinical and immune risk factors for prostatic inflammation or infection were analyzed by using the logistic regression method.Results：Abnormal white blood cell count in urinalysis,prostatic infection and a high concentration of C3 in PF are the risk factors for prostatic inflammation extent.Conclusion：The present study suggests that prostatic inflammation in BPH patients undergoing TURP is associated with urinary tract infection,prostatic infection and the activated complement.