大剂量碘油治疗原发性巨块型肝癌的疗效分析

The utility of large dosage lipiodol treatment in huge primary hepatic carcinoma

【目的】回顾性分析巨块型肝癌经肝动脉灌注化疗并大剂量碘油加化疗药栓塞治疗的临床疗效。【方法】150例原发性巨块型肝癌患者,经皮股动脉穿刺插管至肝动脉,化疗栓塞治疗肝癌;碘油用量为20～60 ml。再注入明胶海绵颗粒栓塞治疗。发现肝外肿瘤供血动脉,超选择插管化疗栓塞后,注入适量明胶海绵栓塞治疗。【结果】治疗的总有效率(RR)为77.3%,治疗后1、2、3年生存率分别为78%、59.3%、45.3%。介入术后未出现严重并发症。【结论】原发性巨块型肝癌大剂量碘油栓塞联合肝外肿瘤供血动脉介入治疗,对于提高疗效具有重要意义。

【Objective】To investigate the clinical efficacy of transcatheter arterial chemoembolization（TACE）with large dosage iodized oil（lipiodol）in huge primary hepatic carcinoma（PHC）via injecting from hepatic artery.【Methods】One hundred fifty cases of diagnosed huge primary liver cancerwere treated by TACE through trans-femoral-artery-catheterwith 20～60ml lipiodol and sufficientgelatin sponge.Super-selective catheterization and transcatheter dual arterial chemoembolization to extraheptic arterialwas preformed.【Results】The overall response rate was 77.3%,the 1,2,3 years survival rates after treatment were 78%、 45.3%、11.3%.No severe complications happened in this series.【Conclusion】High dose lipiodol TACE combinedwith interventional treatment-ofextrahepatic arterieshave very important clinical significance forbetter efficacy of huge primary liver cancer patients.