摘要
目的:检测人肝细胞肝癌中是否存在肝内干细胞(又称为肝前体细胞)以及分化状态如何,并探讨骨髓干细胞在肝细胞肝癌的病理过程中是否发挥作用。方法:用免疫组织化学法检测40例肝癌组织及癌旁组织中的HepParl(肝细胞标志物)、CK7和CK19(胆管细胞分化标志物)以及CD90(骨髓干细胞标志物)的表达情况。结果:在肿瘤结节边缘及肝硬化的门脉区可发现肝前体细胞的存在,并且HepParl、CK7和CK19表达阳性,而CD90表达阴性。结论:肝细胞肝癌可能是在肝前体细胞长期突变积累的基础上发展而成。
Objective：To detect the existence and the differentiation status of intrahepatic stem cells（also known as hepatic progenitor cells） in hepatocellular carcinoma and whether the haemopoietic stem cells are involved in the pathogenesis of hepatocellular carcinoma.Methods：Immunohistochemistry was performed on 40 paraffin-embedded hepatocellular carcinoma specimens with the marker of hepatocyte（HepParl）,the markers of biliary differentiation（CK7 and CK19） and the marker of haemopoietic stem cell（CD90）.Results：The intrahepatic stem cells can be identified around the edge of tumor nodules and in the portal tracts of the para-cirrhosis nodules with positive in HepParl,CK7 and CK19,but failed to immunostained with CD90.Conclusion：Human hepatocellular carcinogenisis may be based on malignant transformation of intrahepatic stem cells.
出处
《内蒙古医学院学报》
2011年第1期1-4,共4页
Acta Academiae Medicinae Neimongol
