摘要
目的:探讨Survivin、γ-catenin蛋白在结直肠癌中的表达及其与结直肠癌发生、发展的关系。方法:采用免疫组织化学方法检测结直肠癌及癌旁组织中Suvrivin、γ-catenin蛋白的表达,应用SPSS13.0软件进行统计。结果:Survivin蛋白在结直肠癌组织中的阳性表达量与癌旁组织相比明显增高(P<0.01),并与大肠癌的分化程度、淋巴转移相关(P<0.01)。γ-catenin蛋白在大肠癌组织中的阳性表达量与癌旁组织相比明显降低(P<0.01),并与大肠癌的分化程度、淋巴转移有关(P<0.05)。结论:Survivin蛋白在结直肠癌组织中的阳性表达量明显增高、γ-catenin蛋白的表达量明显降低,两者可能在大肠癌的发生、发展及转移中发挥重要作用,并与大肠癌病理特征和生物学行为存在密切关系,探讨其表达对结直肠癌的诊断治疗及预后有一定的意义。
Objective： To explore the expression of survivin and γ-catenin in colorectal cancer and its clinical significance.Methods：The expression of survivin and γ-catenin was detected in 60 cases of colorectal cancer and adjacent tissues using immunohistochemistry.The relationship of the expression and clinical pathological parameters were analysed using SPSS13.0 software.Results：The expression of survivin in colorectal cancer was higher than that in adjacent tissues（P〈0.01）and was related with the differentiation and lymph node metastasis of cancer tissues（P〈0.01）.While the expression of catenin lower than that in adjacent tissues（P〈0.01）and was related with the differentiation and lymph metastasis of cancer tissues（P〈0.05）.Conclusion：The relatively higher and lower expression of survivin and γ-catenin in colorectal cancer may play important role in the carcinogenesis,progression and metastasis and have a close relationship with pathological features and biological behaviour of colorectal cancer.This study may have certain significance to the diagnosis,treatment and prognosis of colorectal cancer.
出处
《内蒙古医学院学报》
2011年第1期5-8,共4页
Acta Academiae Medicinae Neimongol
