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窄谱中波紫外线对特应性皮炎患者外周血Th1/Th2表达失衡的影响 被引量：5

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摘要 65例特应性皮炎(AD)患者使用NB-UVB照射治疗,采用酶联免疫吸附法(ELISA)检测光疗前后血清IFN-γ、IL-12、II-4及IL-13的含量,并对其临床疗效进行评价。同时选30名健康查体者作为正常对照组。AD患者血清IL-4和IL-13水平显著高于正常对照组(P<0.05);IFN-γ略高于正常对照组(P>0.05);IL-12略低于正常对照组(P>0.05)。NB-UVB治疗后血清IL-4和IL-13水平降低,与治疗前相比均有显著性差异(P<0.05);IFN-γ和IL-12水平略降低,与治疗前相比无显著性差异(P>0.05)。NB-UVB照射可下调外周血IL-4及IL-13水平,从而使Th1/Th2表达趋于平衡,这可能是NB-UVB治疗特应性皮炎的机制之一。
作者 王忠永 邱盼盼 邱会芬 蒋延伟 张玉杰 高昱
机构地区 滨州医学院附属医院皮肤科
出处 《中国麻风皮肤病杂志》 2011年第5期324-326,共3页 China Journal of Leprosy and Skin Diseases
基金 滨州医学院科技计划(编号:BY2009KJ34)
关键词 特应性皮炎 窄谱中波紫外线 IFN-y IL-12 IL-4 IL-13
分类号 R758.2 [医药卫生—皮肤病学与性病学]
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参考文献12

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二级参考文献14

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共引文献161

同被引文献45

  • 1阳忠辉,张玉环,焦振山.牛磺酸对特应性皮炎患者Th1/Th2细胞因子的影响[J].中国中西医结合皮肤性病学杂志,2005,4(2):87-89. 被引量：4
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  • 10冯同喜,曹晶晶,杜华,杨桂兰.窄谱中波紫外线对银屑病患者CCR2 mRNA表达的影响[J].中国皮肤性病学杂志,2008,22(9):532-534. 被引量：8

引证文献5

二级引证文献21

中国麻风皮肤病杂志
2011年 第5期

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