颈动脉粥样硬化病人血清免疫修饰低密度脂蛋白的测定及意义

The meaning of serum low density lipoprotein immune complexes assay in carotid atherosclerosis patients

目的观察颈动脉粥样硬化（CAS）病人血清免疫修饰低密度脂蛋白（LDL—IC）含量的变化，说明LDL－IC与动脉粥样硬化（AS）的关系。方法通过复式超声确诊CAS病人78例，用酶联免疫吸附试验测定血清LDL－IC含量。结果CAS组血清LDL-IC含量为47．70士23．04AU；对照组为27．52土11．58AU。两组之间LDL－IC含量存在显著性差异（P<0.001）。结论LDL－IC与AS有密切关系。LDL－IC可反映体内各种化学修饰低密度脂蛋白的总情况。

Objective To observe the level of low density lipoprotein immune complexes (LDL-IC) incarotid atherosclerosis (CAS) patients. To explain the realtion between LDL-IC and atherosclerosis (AS).Methods Seventy-eight CAS patients were diagnosed by ultrasonic examination. The level of serum LDL-IC were assayed by enzyme linked immunosorbent assay. Results The level of serum LDL-IC was 47. 70±23.04 AU in CAS patients. The level of serum LDL-IC was 27. 52±11.58 AU in control subject. Thecontents of LDL-IC was significantly higher in CAS patients than in control subject (P<0.001 ).Conclusions There was a close realtion between LDL-IC and AS. The level of LDL-IC could representthe whole degree of all kinds of chemically modified low density lipoprotein in vivo.