多孔CPC在体外静态和动态模拟体液环境下降解性的对比研究

A Comparative Study of the in vitro Degradation of Porous Calcium Phosphate Cements Scaffold in Static and Dynamic Simulated Body Fluid

比较静态和动态模拟体液环境下多孔CPC材料的降解特性。将制备好的多孔CPC材料分别浸泡在静态模拟体液和与人体体液生理流速相同的动态模拟体液中,于浸泡后4、8、16、24周取样,扫描电镜观察材料结构变化,能谱分析材料孔隙表面化学组成变化,测定孔隙率、失重率和力学强度改变。结果在静态模拟体液环境下,材料表面及内部孔隙均可见到类骨样磷灰石层沉积;而动态模拟环境下,仅在材料内部孔隙有部分磷灰石层沉积。与静止的模拟体液相比,动态的模拟体液内浸泡的多孔CPC材料孔隙率增加及材料的质量和力学强度下降更为明显。说明与静态模拟体液环境比较,多孔CPC材料浸泡在动态模拟环境下的降解更为明显。

The goal of this study was to compare the degradation characteristics and kinetics of porous CPC in dynamic simulated body fluid（DSBF） and in static simulated body fluid（SSBF） in vitro.The test was performed in DSBF and SSBF condition in vitro.After 4,8,16 and 24 weeks,the porous structure of CPCs was observed by SEM and the chemical compositions on the surfaces of the samples were analyzed by using energy dispersive spectroscopy.At the same time,the cumulative mass loss（%）,porosity and compressive strength of samples were examing at different degradation time.Bone-like apatite formation was relatively easier to occur in static SBF than in dynamic SBF.The increase in porosity and decrease in mass and compressive strength of porous CPC were faster in dynamic SBF than in static SBF.It is conclused that rate of degradation of porous CPC is faster in dynamic SBF than in static SBF.